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. 2023 Nov 1;49(11):508-510.
doi: 10.1097/ICL.0000000000001029. Epub 2023 Aug 24.

Examination of the Corneal Endothelium in Pediatric Patients With COVID-19

Gizem Gürbostan Soysal  1 , Sevim Ayça Seyyar, Sabit Kimyon, Alper Mete, Kıvanç Güngör
Affiliations

Examination of the Corneal Endothelium in Pediatric Patients With COVID-19

Gizem Gürbostan Soysal et al. Eye Contact Lens. .

Abstract

Purpose: To investigate the effects of coronavirus disease 2019 (COVID-19) infection on the corneal endothelium in children.

Methods: This retrospective study included 46 pediatric patients with COVID-19 infection and 38 healthy controls. Specular microscopy measurements were analyzed, and measurements were obtained from images showing at least 100 cells with clear borders. Mean endothelial cell density, mean hexagonal cell percentage (HEX), mean coefficient of variation (CV), central corneal thickness, and mean cell area were evaluated.

Results: Specular microscopy data showed that the CV values were 2.442±6.517 in the healthy control group (HCG) and 2.659±5.119 in the COVID-19-affected group (CAG) ( P =0.003). The hexagonality of the HCG and CAG were 6.916±8.271 and 6.683±5.885, respectively ( P =0.011).

Conclusion: A decrease in the HEX and an increase in the CV were observed in the corneal specular microscopic examination of children with COVID-19 infection. These results are important in demonstrating the corneal effects of COVID-19 infection in children.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

References

    1. Ladhani SN, Amin-Chowdhury Z, Davies HG, et al. COVID-19 in children: Analysis of the first pandemic peak in England. Arch Dis Child 2020;105:1180–1185.
    1. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese center for disease control and prevention. JAMA 2020;323:1239–1242.
    1. Bi Q, Wu Y, Mei S, et al. Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: A retrospective cohort study. Lancet Infect Dis 2020;20:911–919.
    1. Chen L, Liu M, Zhang Z, et al. Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease. Br J Ophthalmol 2020;104:748–751.
    1. Ma N, Li P, Wang X, et al. Ocular manifestations and clinical characteristics of children with laboratory-confirmed COVID-19 in Wuhan, China. JAMA Ophthalmol 2020;138:1079–1086.