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. 2023 Aug 25;13(1):13903.
doi: 10.1038/s41598-023-41233-y.

Serum NT-proBNP level for predicting functional outcomes after acute ischemic stroke

Phattheera Srisujikul #  1 , Kitti Thiankhaw #  2   3 , Surat Tanprawate  4   5 , Atiwat Soontornpun  4   5 , Chayasak Wantaneeyawong  4   5 , Chutithep Teekaput  4   5 , Nopdanai Sirimaharaj  4   5 , Angkana Nudsasarn  5
Affiliations

Serum NT-proBNP level for predicting functional outcomes after acute ischemic stroke

Phattheera Srisujikul et al. Sci Rep. .

Abstract

N-terminus pro-brain natriuretic peptide (NT-proBNP) has been studied and recognized as a biomarker of cardiac thrombogenicity and stroke risk. However, the association between NT-proBNP and functional outcomes following acute ischemic stroke is still debated. This study aimed to investigate whether serum NT-proBNP level is associated with functional outcomes in acute ischemic stroke individuals. This prospective cohort study included patients diagnosed with acute ischemic stroke, and serum NT-proBNP levels were measured within 72 h. At 3 months, all patients were followed up for a modified Rankin Scale (mRS), and logistic regression models were used to evaluate the association of NT-proBNP on the primary outcome, in which a score of 3-6 was classified as an unfavorable functional outcome. Sixty-seven patients were enrolled in the study, and 23 (34.3%) patients were identified with an unfavorable functional outcome. Elevated serum NT-proBNP levels (> 100 pg/mL) were observed in 57 (85.1%) patients, and the Youden index demonstrated a cutpoint estimation of poor outcomes at 476 pg/mL with 74% sensitivity and 63% specificity. Multivariate regression analysis showed an elevation of NT-proBNP above the cutpoint level was an independent predictor for unfavorable functional outcomes, odds ratio 3.77, 95% confidence interval (1.04-13.62), P = 0.04. The present study demonstrated that elevated serum NT-proBNP levels were expected among acute ischemic stroke patients and represented the risk of unfavorable functional outcomes, suggesting that NT-proBNP might be a useful biomarker for predicting prognosis after ischemic stroke.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flow chart of included participants.
Figure 2
Figure 2
NT-proBNP levels and 90-day functional outcomes of participants.
Figure 3
Figure 3
Receiver operating characteristic (ROC) curve of NT-proBNP cutpoint levels for predicting an unfavorable functional outcome (mRS ≥ 3).
See this image and copyright information in PMC

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