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. 2023 Aug 25;12(1):149.
doi: 10.1186/s13643-023-02320-3.

A systematic review of early motor interventions for infants with congenital heart disease and open-heart surgery

Rahel Kaeslin  1   2 , Beatrice Latal  1   2   3 , Elena Mitteregger  4   5   6
Affiliations

A systematic review of early motor interventions for infants with congenital heart disease and open-heart surgery

Rahel Kaeslin et al. Syst Rev. .

Abstract

Background: Motor development delay is the first neurodevelopmental impairment that becomes apparent in infants with congenital heart disease (CHD). Early interventions have addressed high-risk groups like infants born preterm, but little is known about interventions to improve motor outcome in CHD infants at risk of motor delay. The purpose of this review was to systematically review the literature on type and effect of motor intervention applied during the first year of life in infants with CHD following open-heart surgery.

Methods: Scoping searches were performed in May 2020 and April 2023 via MEDLINE, Embase, CINAHL, Cochrane, PsycINFO, PEDro, and Scopus. The review included studies published in English from 2015 to 2022. Primary outcome was infants' motor development measured by standardized and non-standardized motor assessments, and if available, infants' language and cognitive development, and any parental quality-of-life assessments as secondary outcomes. The studies' quality was evaluated with a modified Newcastle-Ottawa scale.

Results: Four papers with low to high methodological quality met inclusion criteria. All studies investigated the influence of early physiotherapy. Four studies involved parents, and three studies used standardized tools to assess motor outcomes. No conclusion can be drawn about any positive effect of early motor interventions.

Conclusions: Early motor intervention in CHD infants may improve motor development; however, the few existing studies do not provide clear evidence. Thus, more prospective early intervention studies are needed.

Trial registration: PROSPERO CRD42020200981.

Keywords: Child; Congenital heart disease; Early motor intervention; Exercise; Infant; Motor outcome; Open-heart surgery; Parental involvement and consulting; Physiotherapy.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA 2020 flow diagram for new systematic reviews which included searches of databases and registers only
See this image and copyright information in PMC

References

    1. Liu Y, Chen S, Zühlke L, Black GC, Choy MK, Li N, et al. Global birth prevalence of congenital heart defects 1970–2017: updated systematic review and meta-analysis of 260 studies. Int J Epidemiol. 2019;48(2):455–63. doi: 10.1093/ije/dyz009. - DOI - PMC - PubMed
    1. van der Linde D, Konings EE, Slager MA, Witsenburg M, Helbing WA, Takkenberg JJ, et al. Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Coll Cardiol. 2011;58(21):2241–7. doi: 10.1016/j.jacc.2011.08.025. - DOI - PubMed
    1. Mitchell SC, Korones SB, Berendes HW. Congenital heart disease in 56,109 births Incidence and natural history. Circulation. 1971;43(3):323–32. doi: 10.1161/01.cir.43.3.323. - DOI - PubMed
    1. Marelli AJ, Ionescu-Ittu R, Mackie AS, Guo L, Dendukuri N, Kaouache M. Lifetime prevalence of congenital heart disease in the general population from 2000 to 2010. Circulation. 2014;130(9):749–56. doi: 10.1161/circulationaha.113.008396. - DOI - PubMed
    1. Peyvandi S, Latal B, Miller SP, McQuillen PS. The neonatal brain in critical congenital heart disease: insights and future directions. Neuroimage. 2019;185:776–82. doi: 10.1016/j.neuroimage.2018.05.045. - DOI - PubMed

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