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Review
. 2023 Jul 31;11(8):2153.
doi: 10.3390/biomedicines11082153.

Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea: Previous Understanding and Updates

Chengqian Chen  1 , Peiru Wang  1 , Linglin Zhang  1 , Xiaojing Liu  1 , Haiyan Zhang  1 , Yajing Cao  1 , Xiuli Wang  1 , Qingyu Zeng  1
Affiliations
Review

Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea: Previous Understanding and Updates

Chengqian Chen et al. Biomedicines. .

Abstract

Rosacea is a chronic inflammatory skin disease characterized by recurrent erythema, flushing, telangiectasia, papules, pustules, and phymatous changes in the central area of the face. Patients with this condition often experience a significant negative impact on their quality of life, self-esteem, and overall well-being. Despite its prevalence, the pathogenesis of rosacea is not yet fully understood. Recent research advances are reshaping our understanding of the underlying mechanisms of rosacea, and treatment options based on the pathophysiological perspective hold promise to improve patient outcomes and reduce incidence. In this comprehensive review, we investigate the pathogenesis of rosacea in depth, with a focus on emerging and novel mechanisms, and provide an up-to-date overview of therapeutic strategies that target the diverse pathogenic mechanisms of rosacea. Lastly, we discuss potential future research directions aimed at enhancing our understanding of the condition and developing effective treatments.

Keywords: inflammation; inflammatory skin disease; pathogenesis; rosacea; therapeutic strategies; treatment options.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic diagram illustrating the original and emerging factors implicated in the pathogenesis of rosacea. The figure was created with BioRender.com (accessed on 28 June 2023).
Figure 2
Figure 2
Schematic representation of TLR2/KLK5/LL37 pathway. The red arrows in the figure signify a positive feedback loop, which contributes to the chronicity of the disease. The figure was created with BioRender.com (accessed on 28 June 2023).
Figure 3
Figure 3
Cells and microbes involved in the immune state of rosacea. The figure was created with BioRender.com (accessed on 28 June 2023).
Figure 4
Figure 4
Schematic illustration depicting the intricate interplay among nerves, blood vessels, and immune cells in the development of rosacea. The figure was created with BioRender.com (accessed on 28 June 2023).
Figure 5
Figure 5
Major factors involved in the pathophysiology of rosacea. The figure was created with BioRender.com (accessed on 28 June 2023).
See this image and copyright information in PMC

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