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Review
. 2023 Aug 8;15(16):4017.
doi: 10.3390/cancers15164017.

MicroRNAs Derived from Extracellular Vesicles: Keys to Understanding SARS-CoV-2 Vaccination Response in Cancer Patients?

Beatriz Almeida  1   2 , Tânia R Dias  1   3 , Ana Luísa Teixeira  1 , Francisca Dias  1 , Rui Medeiros  1   3   4   5   6
Affiliations
Review

MicroRNAs Derived from Extracellular Vesicles: Keys to Understanding SARS-CoV-2 Vaccination Response in Cancer Patients?

Beatriz Almeida et al. Cancers (Basel). .

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provoked a global pandemic identified as coronavirus disease (COVID-19), with millions of deaths worldwide. However, several important questions regarding its impact on public health remain unanswered, such as the impact of vaccination on vulnerable subpopulations such as cancer patients. Cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion, being manifested in most immunocompromised individuals. This strong immunosuppression can lead to a dysfunctional antiviral response to natural viral infection and compromised vaccination response. Extracellular vesicles (EVs) are membrane-bound vesicles released from cells that are involved in intercellular communication. EVs carry various molecules including microRNAs that play a crucial role in COVID-19 pathophysiology, influencing cellular responses. This review summarizes the state of the art concerning the role of EV-derived miRNAs in COVID-19 infection and their potential use as prognosis biomarkers for vaccination response in cancer patients.

Keywords: SARS-CoV-2; extracellular vesicles; microRNAs.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
EV-derived microRNAs present in the 7 original articles selected in this review, with the principal conclusion in each study. Created with BioRender.com (accessed on 10 July 2023).
Figure 2
Figure 2
Study design of the two selected miRNAs, hsa-miR-24-3p and hsa-miR-145-5p, in cancer patients with SARS-CoV-2 infection and/or COVID-19 vaccination for predictive biomarkers in a more personalized treatment. Created with BioRender.com (accessed on 10 July 2023).
See this image and copyright information in PMC

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