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. 1986 Oct;323(6088):508-14.
doi: 10.1038/323508a0.

Structure, sequence and expression of the hepatitis delta (delta) viral genome

K S Wang, Q L Choo, A J Weiner, J H Ou, R C Najarian, R M Thayer, G T Mullenbach, K J Denniston, J L Gerin, M Houghton

Structure, sequence and expression of the hepatitis delta (delta) viral genome

K S Wang et al. Nature. 1986 Oct.

Erratum in

  • Nature 1987 Jul 30-Aug 5;328(6129):456

Abstract

Biochemical and electron microscopic data indicate that the human hepatitis delta viral agent contains a covalently closed circular and single-stranded RNA genome that has certain similarities with viroid-like agents from plants. The sequence of the viral genome (1,678 nucleotides) has been determined and an open reading frame within the complementary strand has been shown to encode an antigen that binds specifically to antisera from patients with chronic hepatitis delta viral infections.

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