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. 2023 Aug 18;15(16):4170.
doi: 10.3390/cancers15164170.

Obstetric Results after Fertility-Sparing Management of Non-Epithelial Ovarian Cancer

Szymon Piątek  1   2 , Iwona Szymusik  3 , Piotr Sobiczewski  1 , Wojciech Michalski  1 , Magdalena Kowalska  1 , Mariusz Ołtarzewski  4 , Mariusz Bidziński  1   2
Affiliations

Obstetric Results after Fertility-Sparing Management of Non-Epithelial Ovarian Cancer

Szymon Piątek et al. Cancers (Basel). .

Abstract

Purpose: To assess the recurrence and birth rates among patients with non-epithelial ovarian cancer.

Methods: The study included 146 patients with germ cell (GCT, n = 84) and sex cord-stromal tumors (SCST, n = 62), who underwent fertility-sparing surgery. Adjuvant chemotherapy was administered to 86 (58.9%) patients. Most cases (133 out of 146) were staged FIGO I.

Results: The 5- and 10-year disease-free survival rates were 91% and 83%, respectively. The recurrence risk was not associated with tumor histology, stage or age. Twenty-four months after the treatment, the rate of recurrence was higher than the rate of childbearing. The childbearing rates kept rising after the treatment and exceeded the rate of recurrence after 2 years. The cumulative incidence rates of birth 36, 60 and 120 months after treatment were 13.24%, 20.75%, and 42.37%, respectively. Chemotherapy was not related to childbearing. The patients' age was related to the chance of childbearing.

Conclusions: The prognoses of GCT and SCST are similar. Close follow-ups along with contraception should be offered to women during the first two years after treatment due to the increased risk of recurrence. After this period, relapses are rare and women can safely become pregnant.

Keywords: birth rate; fertility-sparing surgery; germ cell tumor; non-epithelial ovarian cancer; obstetric outcome; recurrence; sex cord-stromal tumor.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The flowchart of the study.
Figure 2
Figure 2
Disease-free survival (DFS) in patients according to histopathological examination (A), staging (B) and restaging surgery (C).
Figure 2
Figure 2
Disease-free survival (DFS) in patients according to histopathological examination (A), staging (B) and restaging surgery (C).
Figure 3
Figure 3
Cumulative incidence rates of childbearing according to: (A) stage, (B) chemotherapy (CTH: chemotherapy), and (C) age.
Figure 3
Figure 3
Cumulative incidence rates of childbearing according to: (A) stage, (B) chemotherapy (CTH: chemotherapy), and (C) age.
Figure 4
Figure 4
Cumulative incidence rates of childbearing and recurrence in patients with NEOC after FSM.
See this image and copyright information in PMC

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