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. 2023 Aug 14;13(16):2668.
doi: 10.3390/diagnostics13162668.

Choroid Plexus Volume Change-A Candidate for a New Radiological Marker of MS Progression

Anna Jankowska  1 , Kamil Chwojnicki  2 , Małgorzata Grzywińska  3 , Piotr Trzonkowski  4 , Edyta Szurowska  1
Affiliations

Choroid Plexus Volume Change-A Candidate for a New Radiological Marker of MS Progression

Anna Jankowska et al. Diagnostics (Basel). .

Abstract

(1) Background: Multiple sclerosis (MS) is an auto-immune, chronic, neuroinflammatory, demyelinating disease that affects mainly young patients. This progressive inflammatory process causes the chronic loss of brain tissue and results in a deterioration in quality of life. To monitor neuroinflammatory process activity and predict the further development of disease, it is necessary to find a suitable biomarker that could easily be used. In this research, we verify the usability of choroid plexus (CP) volume, a new MS biomarker, in the monitoring of the progression of multiple sclerosis disease. (2) Methods: A single-center, prospective study with three groups of patients was conducted based on the following groups: MS patients who received experimental cellular therapy (Treg), treatment-naïve MS patients and healthy controls. (3) Results: This study concludes that there is a correlation between the CPV/TIV (choroid plexus/total intracranial volume) ratio and the progress of multiple sclerosis disease-patients with MS (MS + Treg) had larger volumes of choroid plexuses. CPV/TIV ratios in MS groups were constantly and significantly growing. In the Treg group, patients with relapses had larger plexuses in comparison to the group with no relapses of MS. A similar correlation was observed for the GD+ group (patients with postcontrast enhancing plaques) compared against the non-GD group (patients without postcontrast enhancing plaques). (4) Conclusion: Choroid plexus volume, due to its immunological function, correlates with the inflammatory process in the central nervous system. We consider it to become a valuable radiological biomarker of MS activity.

Keywords: biomarker; choroid plexus; magnetic resonance; multiple sclerosis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Segmented choroid plexuses in BrainMagix software.
Figure 2
Figure 2
The lack of correlation between plaques volume and CP annual change for both MS groups.
Figure 3
Figure 3
The lack of correlation between plaques volume and brain volume for both MS groups.
See this image and copyright information in PMC

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