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. 2023 Aug 16;11(16):2312.
doi: 10.3390/healthcare11162312.

The Non-Paced 3-Minute Sit-to-Stand Test: Feasibility and Clinical Relevance for Pulmonary Rehabilitation Assessment

Rachel Ernst  1 , Benoit Bouteleux  1 , Marie Malhouitre  1 , Léo Grassion  2 , Maéva Zysman  2   3 , Pauline Henrot  3   4 , Mathieu Delorme  1   5
Affiliations

The Non-Paced 3-Minute Sit-to-Stand Test: Feasibility and Clinical Relevance for Pulmonary Rehabilitation Assessment

Rachel Ernst et al. Healthcare (Basel). .

Abstract

Pulmonary rehabilitation (PR) improves health-related quality-of-life (HRQoL) in individuals with chronic obstructive pulmonary disease (COPD), notably by increasing exercise tolerance. Easy-to-implement sit-to-stand tests can facilitate the assessment of exercise tolerance in routine practice. This retrospective study conducted in a real-life setting was designed to describe the non-paced 3-min sit-to-stand test (3-STST) and to evaluate its relationship with HRQoL (VQ11 questionnaire) to identify the determinants of 3-STST performance and to analyze the evolution of 3-STST performance and HRQoL over the course of a community-based PR program. Seventy-one COPD patients (age 69 ± 10 years old; 51% with GOLD spirometric stages III-IV) were included. Mean ± SD 3-STST performance at the initial PR assessment was 43 ± 15 repetitions. This performance was significantly associated with HRQoL and other indicators of clinical severity (lung function, dyspnea, and functional capacities). During the multivariate analysis, younger age, exertional dyspnea with mMRC ≤ 1, and better HRQoL were significantly associated with better 3-STST performance. From the initial to second PR assessment, changes in 3-STST performance were significantly associated with changes in HRQoL. This study provides evidence that the non-paced 3-STST is feasible and might be clinically relevant in the assessment of patients with COPD referred for community-based PR. This test deserves to be prospectively validated.

Keywords: chronic obstructive pulmonary disease; exercise training; health-related quality-of-life; pulmonary rehabilitation; sit-to-stand test.

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Conflict of interest statement

MD reports personal fees from Air Liquide Medical Systems, Breas Medical AB, GSK, and ResMed SAS and non-financial support from L3 Medical, ISIS Medical, and SOS Oxygene outside of the submitted work. PH reports grants from Fondation Bordeaux Université with funding from FGLMR/Avad and non-financial support from Chiesi outside of the submitted work. LG received grants or contracts from AADAIRC outside of the submitted work; payment of honoraria for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events from SOS Oxygene, ASTEN Santé, CHIESI, SANOFI, ASTRA ZENECA, ASV Santé, and ALMS outside of the submitted work; support for attending meetings and/or travel from SOS Oxygen, ALIZE, VIVISOL, and ASTEN Santé outside of the submitted work; and participation on a data safety monitoring board or advisory board for RESMED, ALMS, and VIVISOL outside of the submitted work. The other authors have no conflict of interest to disclose.

Figures

Figure 1
Figure 1
Study flow chart. Non-paced 3-STST, non-paced three-minute sit-to-stand test; COPD, chronic obstructive pulmonary disease; PR, pulmonary rehabilitation.
Figure 2
Figure 2
Relationship between the non-paced 3-min sit-to-stand test, health-related quality-of-life (VQ11 questionnaire), and 6-min walking test distance. 3-STST, non-paced three-minute sit-to-stand test; 6-MWT, 6-min walking test. (A) Relationship between 3-STST and VQ11 total score; (B) relationship between 3-STST and 6-MWT distance. A lower VQ11 score indicates better HRQoL.
Figure 3
Figure 3
Relationship between changes in 3-STST performance from the first to second assessment compared to changes in VQ11 total score (A) and changes in 6-MWT distance (B). 3-STST, non-paced three-minute sit-to-stand test; 6-MWT, 6-min walking test. A reduced VQ11 score indicates improved HRQoL.
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