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Review
. 2023 Aug 18;11(16):2340.
doi: 10.3390/healthcare11162340.

Cost-Effectiveness of Glucosamine in Osteoarthritis Treatment: A Systematic Review

Nam Xuan Vo  1 , Ngan Nguyen Hoang Le  1 , Trinh Dang Phuong Chu  1 , Huong Lai Pham  1 , Khang Xuan An Dinh  1 , Uyen Thi Thuc Che  1 , Thanh Thi Thanh Ngo  1 , Tien Thuy Bui  2
Affiliations
Review

Cost-Effectiveness of Glucosamine in Osteoarthritis Treatment: A Systematic Review

Nam Xuan Vo et al. Healthcare (Basel). .

Abstract

Osteoarthritis (OA) is a chronic condition that most frequently affects older adults. It is currently the most common disability. The cost of treating an aging population places pressure on the healthcare budget. As a result, it is imperative to evaluate medicines' cost-effectiveness and, accordingly, their influence on health resource allocation. Our study aims to summarize the cost and outcome of utilizing glucosamine in OA treatment. Databases like Medline, Cochrane, and Scopus were searched as part of the identification process up until April 2023. Our primary inclusion criteria centered on the economic evaluation of glucosamine in OA treatments, providing an incremental cost-effectiveness ratio (ICER). The Quality of Health Economic Studies (QHES) instrument was applied to grade the quality of the studies. Seven qualified studies that discussed the cost-effectiveness of glucosamine with or without other formulations were selected. All of them demonstrated that glucosamine was cost-effective. There was an increase in quality-adjusted life years (QALYs) when incorporating glucosamine in conventional care. Moreover, patented crystalline glucosamine sulfate (pCGS) was more cost-effective than the other formulations of glucosamine (OFG). Overall, utilizing pCGS was more beneficial than using OFG in terms both of cost and quality of life.

Keywords: cost-effectiveness; economic evaluation; glucosamine; osteoarthritis; systematic review.

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Conflict of interest statement

The authors declare no conflict of interest.

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Figure 1
Process of article selection.
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