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Review
. 2023 Aug 13;14(8):1619.
doi: 10.3390/genes14081619.

Genetic and Epigenetic Mechanisms of Psoriasis

Laura Mateu-Arrom  1 , Lluis Puig  1
Affiliations
Review

Genetic and Epigenetic Mechanisms of Psoriasis

Laura Mateu-Arrom et al. Genes (Basel). .

Abstract

Psoriasis is a disease involving the innate and adaptative components of the immune system, and it is triggered by environmental factors in genetically susceptible individuals. However, its physiopathology is not fully understood yet. Recent technological advances, especially in genome and epigenome-wide studies, have provided a better understanding of the genetic and epigenetic mechanisms to determine the physiopathology of psoriasis and facilitate the development of new drugs. This review intends to summarize the current evidence on genetic and epigenetic mechanisms of psoriasis.

Keywords: epigenomics; genetics; psoriasis.

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Conflict of interest statement

L. Mateu-Arrom declare no conflict of interest L. Puig has perceived consultancy/speaker’s honoraria from and/or participated in clinical trials sponsored by Abbvie, Almirall, Amgen, Biogen, Boehringer Ingelheim, Bristol Myers Squibb, Janssen, Leo-Pharma, Lilly, Novartis, Pfizer, Sandoz, Sanofi, and UCB.

Figures

Figure 1
Figure 1
Epigenetic alterations that modify gene transcription: DNA methylation and histone modification. Euchromatin and heterochromatin. Unmethylated CpG islands (greencircles), permissive histone modifications (green stars) and loosechromatin structure promote gene transcription. Conversely, DNAmethylation (red circles), repressive histone modifications (red stars) and condensed structure prevent transcription. Although governed bydistinct enzymes, there is cooperativity and interaction between thedifferent epigenetic modifications. TET = Ten-eleven translocationdioxygenase; DNAMT = DNA methyltransferase.
See this image and copyright information in PMC

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