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Review
. 2023 Aug 20;24(16):13002.
doi: 10.3390/ijms241613002.

Targeting SARS-CoV-2 Non-Structural Proteins

Donald Tam  1 , Ana C Lorenzo-Leal  1 , Luis Ricardo Hernández  2 , Horacio Bach  1
Affiliations
Review

Targeting SARS-CoV-2 Non-Structural Proteins

Donald Tam et al. Int J Mol Sci. .

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped respiratory β coronavirus that causes coronavirus disease (COVID-19), leading to a deadly pandemic that has claimed millions of lives worldwide. Like other coronaviruses, the SARS-CoV-2 genome also codes for non-structural proteins (NSPs). These NSPs are found within open reading frame 1a (ORF1a) and open reading frame 1ab (ORF1ab) of the SARS-CoV-2 genome and encode NSP1 to NSP11 and NSP12 to NSP16, respectively. This study aimed to collect the available literature regarding NSP inhibitors. In addition, we searched the natural product database looking for similar structures. The results showed that similar structures could be tested as potential inhibitors of the NSPs.

Keywords: RNA capping machinery; SARS-CoV-2; drug targeting; multi-drug regimen; non-structural protein; replication transcription complex; virulence factors.

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Conflict of interest statement

The authors confirmed that they have nothing to disclose.

Figures

Figure 1
Figure 1
SARS-CoV-2 genome, non-structural proteins, and accessory proteins. S, spike protein; M, membrane protein; E, envelope protein; N, nucleocapsid protein. Created with BioRender.com and adapted from [6].
See this image and copyright information in PMC

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