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Review
. 2023 Aug 14;12(16):5287.
doi: 10.3390/jcm12165287.

Proliferative Vitreoretinopathy: A Reappraisal

Paolo Carpineto  1 , Arturo Maria Licata  1 , Marco Ciancaglini  2
Affiliations
Review

Proliferative Vitreoretinopathy: A Reappraisal

Paolo Carpineto et al. J Clin Med. .

Abstract

Proliferative vitreoretinopathy (PVR) remains the main cause of failure after retinal detachment (RD) surgery. Despite the development of modern technologies and sophisticated techniques for the management of RD, the growth of fibrocellular membranes within the vitreous cavity and on both sides of the retinal surface, as well as intraretinal fibrosis, can compromise surgical outcomes. Since 1983, when the term PVR was coined by the Retina Society, a lot of knowledge has been obtained about the physiopathology and risk factors of PVR, but, despite the proposal of a lot of therapeutic challenges, surgical skills seem to be the only effective way to manage PVR complications.

Keywords: epithelial mesenchymal transition; proliferative vitreoretinopathy; retinal detachment; subretinal fluid; vitreoretinal surgery.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Histological section of subretinal PVR membrane shows long-spaced collagen (type IV) on different magnifications.
Figure 2
Figure 2
Immunohistochemistry on subretinal PVR membrane. Red arrows show presence of CD8 T-cells. Black arrows show nonspecific positivity to other cell markers.
Figure 3
Figure 3
Recurrent retinal detachment due to subretinal PVR.
See this image and copyright information in PMC

References

    1. Gloor B.P., Marmor M.F. Controversy over the etiology and therapy of retinal detachment: The struggles of Jules Gonin. Surv. Ophthalmol. 2013;58:184–195. doi: 10.1016/j.survophthal.2012.09.002. - DOI - PubMed
    1. The Retina Society Terminology Committee The classification of retinal detachment with proliferative vitreoretinopathy. Ophthalmology. 1983;90:121–125. doi: 10.1016/S0161-6420(83)34588-7. - DOI - PubMed
    1. Kwon O.W., Song J.H., Roh M.I. Retinal Detachment and Proliferative Vitreoretinopathy. Dev. Ophthalmol. 2016;55:154–162. - PubMed
    1. Charteris D.G., Sethi C.S., Lewis G.P., Fisher S.K. Proliferative vitreoretinopathy-developments in adjunctive treatment and retinal pathology. Eye. 2002;16:369–374. doi: 10.1038/sj.eye.6700194. - DOI - PubMed
    1. Idrees S., Sridhar J., Kuriyan A.E. Proliferative Vitreoretinopathy: A Review. Int. Ophthalmol. Clin. 2019;59:221–240. doi: 10.1097/IIO.0000000000000258. - DOI - PMC - PubMed