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Review
. 2023 Aug 14;13(8):1742.
doi: 10.3390/life13081742.

Exercise Effects on Left Ventricular Remodeling in Patients with Cardiometabolic Risk Factors

Evanthia Bletsa  1   2 , Evangelos Oikonomou  1   2 , Kyriakos Dimitriadis  3 , Panagiota K Stampouloglou  1 , Christos Fragoulis  3   4 , Stavroula P Lontou  4 , Emmanouil Korakas  2   5 , Eirini Beneki  3 , Konstantinos Kalogeras  1 , Vaia Lambadiari  2   5 , Konstantinos Tsioufis  3   4 , Manolis Vavouranakis  1 , Gerasimos Siasos  1   2
Affiliations
Review

Exercise Effects on Left Ventricular Remodeling in Patients with Cardiometabolic Risk Factors

Evanthia Bletsa et al. Life (Basel). .

Abstract

Left ventricular (LV) remodeling is a dynamic process, which is characterized by changes in ventricular size, shape, and wall thickness, thus altering myocardial geometry and function, and is considered as a negative prognostic factor in patients with heart failure (HF). Hypertension, type 2 diabetes (T2D), and obesity are strongly correlated with the development and the progression of LV remodeling, LV hypertrophy, and LV systolic and/or diastolic dysfunction. Indeed, the beneficial impact of exercise training on primary and secondary prevention of cardiovascular disease (CVD) has been well-established. Recent studies have highlighted that exercise training enhances functional capacity, muscle strength and endurance, cardiac function, and cardiac-related biomarkers among patients with established coronary artery disease (CAD) or HF, thus substantially improving their cardiovascular prognosis, survival rates, and need for rehospitalization. Therefore, in this review article, we discuss the evidence of LV remodeling in patients with cardiometabolic risk factors, such as hypertension, T2D, and obesity, and also highlight the current studies evaluating the effect of exercise training on LV remodeling in these patients.

Keywords: diabetes; exercise; heart failure; hypertension; obesity; ventricular remodeling.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The pathway from left ventricular hypertrophy to heart failure.
See this image and copyright information in PMC

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