Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Aug 14;13(8):1742.
doi: 10.3390/life13081742.

Exercise Effects on Left Ventricular Remodeling in Patients with Cardiometabolic Risk Factors

Evanthia Bletsa  1   2 , Evangelos Oikonomou  1   2 , Kyriakos Dimitriadis  3 , Panagiota K Stampouloglou  1 , Christos Fragoulis  3   4 , Stavroula P Lontou  4 , Emmanouil Korakas  2   5 , Eirini Beneki  3 , Konstantinos Kalogeras  1 , Vaia Lambadiari  2   5 , Konstantinos Tsioufis  3   4 , Manolis Vavouranakis  1 , Gerasimos Siasos  1   2
Affiliations
Review

Exercise Effects on Left Ventricular Remodeling in Patients with Cardiometabolic Risk Factors

Evanthia Bletsa et al. Life (Basel). .

Abstract

Left ventricular (LV) remodeling is a dynamic process, which is characterized by changes in ventricular size, shape, and wall thickness, thus altering myocardial geometry and function, and is considered as a negative prognostic factor in patients with heart failure (HF). Hypertension, type 2 diabetes (T2D), and obesity are strongly correlated with the development and the progression of LV remodeling, LV hypertrophy, and LV systolic and/or diastolic dysfunction. Indeed, the beneficial impact of exercise training on primary and secondary prevention of cardiovascular disease (CVD) has been well-established. Recent studies have highlighted that exercise training enhances functional capacity, muscle strength and endurance, cardiac function, and cardiac-related biomarkers among patients with established coronary artery disease (CAD) or HF, thus substantially improving their cardiovascular prognosis, survival rates, and need for rehospitalization. Therefore, in this review article, we discuss the evidence of LV remodeling in patients with cardiometabolic risk factors, such as hypertension, T2D, and obesity, and also highlight the current studies evaluating the effect of exercise training on LV remodeling in these patients.

Keywords: diabetes; exercise; heart failure; hypertension; obesity; ventricular remodeling.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The pathway from left ventricular hypertrophy to heart failure.
See this image and copyright information in PMC

References

    1. Mortality G.B.D., Causes of Death C. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385:117–171. doi: 10.1016/S0140-6736(14)61682-2. - DOI - PMC - PubMed
    1. Gupta A., Fonarow G.C. The Hospital Readmissions Reduction Program-learning from failure of a healthcare policy. Eur. J. Heart Fail. 2018;20:1169–1174. doi: 10.1002/ejhf.1212. - DOI - PMC - PubMed
    1. Stein E.J., Fearon W.F., Elmariah S., Kim J.B., Kapadia S., Kumbhani D.J., Gillam L., Whisenant B., Quader N., Zajarias A., et al. Left Ventricular Hypertrophy and Biomarkers of Cardiac Damage and Stress in Aortic Stenosis. J. Am. Heart Assoc. 2022;11:e023466. doi: 10.1161/JAHA.121.023466. - DOI - PMC - PubMed
    1. Lorell B.H., Carabello B.A. Left ventricular hypertrophy: Pathogenesis, detection, and prognosis. Circulation. 2000;102:470–479. doi: 10.1161/01.CIR.102.4.470. - DOI - PubMed
    1. Sharpe N. Left ventricular remodeling: Pathophysiology and treatment. Heart Fail. Monit. 2003;4:55–61. - PubMed