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Review
. 2023 Aug 15;28(16):6078.
doi: 10.3390/molecules28166078.

Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives

Andrei Biţă  1   2 , Ion Romulus Scorei  2 , Maria Viorica Ciocîlteu  2   3 , Oana Elena Nicolaescu  4 , Andreea Silvia Pîrvu  5 , Ludovic Everard Bejenaru  1 , Gabriela Rău  2   6 , Cornelia Bejenaru  7 , Antonia Radu  7 , Johny Neamţu  2   8 , George Dan Mogoşanu  1   2 , Steven A Benner  9
Affiliations
Review

Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives

Andrei Biţă et al. Molecules. .

Abstract

Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide (NAD+) is involved in an extensive spectrum of human pathologies, including neurodegenerative disorders, cardiomyopathy, obesity, and diabetes. Further, healthy aging and longevity appear to be closely related to NAD+ and its related metabolites, including nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). As a dietary supplement, NR appears to be well tolerated, having better pharmacodynamics and greater potency. Unfortunately, NR is a reactive molecule, often unstable during its manufacturing, transport, and storage. Recently, work related to prebiotic chemistry discovered that NR borate is considerably more stable than NR itself. However, immediately upon consumption, the borate dissociates from the NR borate and is lost in the body through dilution and binding to other species, notably carbohydrates such as fructose and glucose. The NR left behind is expected to behave pharmacologically in ways identical to NR itself. This review provides a comprehensive summary (through Q1 of 2023) of the literature that makes the case for the consumption of NR as a dietary supplement. It then summarizes the challenges of delivering quality NR to consumers using standard synthesis, manufacture, shipping, and storage approaches. It concludes by outlining the advantages of NR borate in these processes.

Keywords: efficacy; healthy aging; longevity; nicotinamide riboside; safety; vitamin B3 derivative.

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Conflict of interest statement

The authors declare no conflict of interest. The funder had no role in the design of the study; in the collection, analysis, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
NR borate mass spectrum: 11B (m/z 281); 10B (m/z 280). B: boron; NR: nicotinamide riboside.
Figure 2
Figure 2
pH stability for NR borate.
See this image and copyright information in PMC

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