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Review
. 2023 Aug 11;15(16):3558.
doi: 10.3390/nu15163558.

The Critical Exploration into Current Evidence behind the Role of the Nutritional Support in Adult Patients Who Undergo Haematogenic Stem Cell Transplantation

Piotr Pawłowski  1 , Paulina Pawłowska  2 , Karolina Joanna Ziętara  1 , Marzena Samardakiewicz  3
Affiliations
Review

The Critical Exploration into Current Evidence behind the Role of the Nutritional Support in Adult Patients Who Undergo Haematogenic Stem Cell Transplantation

Piotr Pawłowski et al. Nutrients. .

Abstract

Haematopoietic stem cell transplantation (HSCT) is a treatment option for many haematological conditions in patients of all ages. Nutritional support is important at each stage of treatment, but particular nutritional needs and dictated support occur during the preparatory (conditioning regimen) and post-transplant periods. Patients may require nutritional treatment by the enteral or parenteral route. The quantitative and qualitative composition of meals may change. Vitamin requirements, including vitamin D and vitamin C, might also be different. An adequately composed diet, adapted to the needs of the patient, may influence the occurrence of complications such as graft-versus-host disease (GvHD), gastrointestinal disorders, infections, and reduced survival time. Haematological diseases as well as transplantation can negatively affect the intestinal flora, with negative consequences in the form of mucosal inflammation and disorders of a functional nature. Currently, aspects related to nutrition are crucial in the care of patients after HSCT, and numerous studies, including randomized trials on these aspects, are being conducted. This study serves the critical analysis of current scientific evidence regarding nutritional support for patients after HSCT.

Keywords: HSCT; haematogenic stem cell transplantation; haematooncology; nutrition; nutritional support.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 2
Figure 2
Bacterial strains used in probiotic therapy (based on [112,122,123,124,125,126,127,128,129,130,131,132,133]).
Figure 1
Figure 1
Prohibited products in the neutropenic diet (based on [69]).
See this image and copyright information in PMC

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