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Observational Study
. 2023 Nov;40(11):2715-2723.
doi: 10.1007/s10815-023-02922-9. Epub 2023 Aug 26.

Impact of maternally derived meiotic aneuploidies on early embryonic development in vitro

Lena Tschare  1   2 , Anna Ennemoser  2 , Luca Carli  2 , Enrico Vaccari  2 , Michael Feichtinger  3
Affiliations
Observational Study

Impact of maternally derived meiotic aneuploidies on early embryonic development in vitro

Lena Tschare et al. J Assist Reprod Genet. 2023 Nov.

Erratum in

Abstract

Purpose: To assess early embryonic developmental potential of embryos affected by maternally inherited meiotic aneuploidies.

Methods: This observational, descriptive study includes 930 oocytes from 151 patients which were retrospectively analyzed by combining the morphological assessment with the genetic results from polar body diagnosis.

Results: Of 930 oocytes examined, 566 (60.9%) were tested aneuploid. Developmental potential until cleavage stage was not affected by trisomies or monosomies (69.6% vs. 77.1%, p = 0.75). However, trisomies significantly more often resulted in top quality cleavage stage embryos compared to monosomies (20% vs. 17.6%, p = < 0.01). Top quality blastocysts were more likely to be euploid than aneuploid (52.4% vs. 47.6%, p = 0.032). Additionally, significantly more aneuploid embryos resulted in developmental arrest compared to euploid embryos (15.3% vs. 6.7%, p = 0.003). Overall, there was no significant difference in the frequency of trisomies and monosomies in blastocyst stage embryos. (28.3% vs. 28.2%; p = 0.81). In contrast to earlier developmental stages, distribution of trisomies and monosomies did not differ in top quality blastocysts (8.3% vs. 5.3%, p = 0.32). However, certain chromosomal abnormalities showed a higher potential to develop into a top-rated blastocyst. These included monosomies 2, 5, 8, 10, 16, 17, 20, 21, and 22 and trisomies 2, 4, 5, 8, 9, 10, 11, 12, 13, 16, 17, 18 and 20.

Conclusion: Meiotically induced maternal aneuploidies have different effects on early embryonic development. While no difference in developmental potential between monosomies and trisomies could be observed in blastocysts, cleavage stage quality was significantly affected by chromosomal aneuploidies.

Keywords: Aneuploidies; Embryo quality; IVF; PGT-A; Polar bodies.

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
Aneuploidy distribution curve in relation to patient age
Fig. 2
Fig. 2
Flowchart of aneuploidy analyzation
Fig. 3
Fig. 3
Frequency of the individual chromosomal monosomies
Fig. 4
Fig. 4
Frequency of the individual chromosomal trisomies
Fig. 5
Fig. 5
Frequency distribution of combined aneuploidies
Fig. 6
Fig. 6
Embryos with of multiple chromosomal maldistributions in relation to patient age
See this image and copyright information in PMC

References

    1. Inhorn MC, Patrizio P. Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century. Hum Reprod Update. 2015;21(4):411–26. 10.1093/humupd/dmv016 - DOI - PubMed
    1. Gruhn JR, Zielinska AP, Shukla V, Blanshard R, Capalbo A, Cimadomo D, et al. Chromosome errors in human eggs shape natural fertility over reproductive life span. Science. 2019;365(6460):1466–9. 10.1126/science.aav7321 - DOI - PMC - PubMed
    1. Hassold T, Hunt P. To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet. 2001;2(4):280–91. 10.1038/35066065 - DOI - PubMed
    1. Lodge C, Herbert M. Oocyte aneuploidy—more tools to tackle an old problem. Proc Natl Acad Sci. 2020;117(22):11850–2. 10.1073/pnas.2005739117 - DOI - PMC - PubMed
    1. Schenk M, Groselj-Strele A, Eberhard K, Feldmeier E, Kastelic D, Cerk S, et al. Impact of polar body biopsy on embryo morphokinetics-back to the roots in preimplantation genetic testing? J Assist Reprod Genet. 2018;35(8):1521–8. 10.1007/s10815-018-1207-4 - DOI - PMC - PubMed

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