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Review
. 2023 Oct:190:104115.
doi: 10.1016/j.critrevonc.2023.104115. Epub 2023 Aug 24.

Combine radiotherapy and immunotherapy in esophageal squamous cell carcinoma

Yicong Chen  1 , Ruixuan Yu  1 , Yongmei Liu  2
Affiliations
Review

Combine radiotherapy and immunotherapy in esophageal squamous cell carcinoma

Yicong Chen et al. Crit Rev Oncol Hematol. 2023 Oct.

Abstract

Immune checkpoint inhibitors(ICIs) have improved the survival of advanced esophageal squamous cell carcinoma (ESCC) patients. Radiotherapy is one of the common therapies to treat esophageal cancer. However, whether combination radiation therapy can increase the efficacy of immunotherapy is still up for debate. Radiotherapy combined with immunotherapy has proven to be a reliable and effective treatment for tumors, and it can work in combination with immunotherapy to achieve better anti-tumor effects. This review aims to discuss the efficacy and safety of combining radiotherapy and immunotherapy to treat ESCC by stages as well as the optimum radiotherapy dose and target volume, with a summary of clinical trials in ESCC.

Keywords: Esophageal squamous cell carcinoma; Immunotherapy; Locally advanced; Neoadjuvant; Radiotherapy.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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