Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jan;1870(1):166858.
doi: 10.1016/j.bbadis.2023.166858. Epub 2023 Aug 25.

Abnormal interaction of Rlip with mutant APP/Abeta and phosphorylated tau reduces wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease

Javaria Baig  1 , Neha Sawant  1 , Priyanka Rawat  1 , Arubala P Reddy  2 , P Hemachandra Reddy  3 , Sudhir Kshirsagar  4
Affiliations
Free article

Abnormal interaction of Rlip with mutant APP/Abeta and phosphorylated tau reduces wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease

Javaria Baig et al. Biochim Biophys Acta Mol Basis Dis. 2024 Jan.
Free article

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that affects a large proportion of the aging population. RalBP1 (Rlip) is a stress-activated protein, that plays an important role in aging and neurodegenerative diseases such as Alzheimer's disease. Mutant APP and mutant Tau interact with the Rlip protein which leads to decreased wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease. Rlip is a promising new target for aging, Alzheimer's disease, and other neurological diseases.

Keywords: Alzheimer's disease; Mitochondrial dysfunction; Oxidative stress; Rlip protein.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare that a pending disclosure is in progress with the contents of this study.

Publication types

LinkOut - more resources