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Case Reports
. 2023 Aug 22:13:27-31.
doi: 10.2147/PTT.S417427. eCollection 2023.

Therapeutic Management of a Case of Severe Psoriasis Coexistent with Bullous Pemphigoid in the Elderly

Vito Di Lernia  1 , Francesca Peccerillo  1 , Elena Ficarelli  1
Affiliations
Case Reports

Therapeutic Management of a Case of Severe Psoriasis Coexistent with Bullous Pemphigoid in the Elderly

Vito Di Lernia et al. Psoriasis (Auckl). .

Abstract

A standardised therapeutic approach to coexistent psoriasis and bullous pemphigoid is lacking, although psoriasis is associated with an increased risk of developing bullous pemphigoid. Here, we report an elderly psoriatic patient who developed a refractory bullous pemphigoid and experienced clearance of both diseases following treatment with dymethylfumarate. Due to lymphopenia, this treatment was stopped and the patient was administered risankizumab without relapses. Dymethylfumarate may be able to inhibit the recruitment of neutrophils and monocytes into the skin. Therefore, thanks to pleiotropic effects, dymethylfumarate could be an effective treatment in psoriatic patients who develop bullous pemphigoid.

Keywords: bullous pemphigoid; elderly; latent tbc; psoriasis; treatment.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Psoriasis worsened (trunk).
Figure 2
Figure 2
Psoriasis worsened (lower limbs).
Figure 3
Figure 3
Clinical remission of both psoriatic e PB lesions on the trunk after DMF therapy.
Figure 4
Figure 4
Clinical remission on lower limbs.
See this image and copyright information in PMC

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