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Case Reports
. 2023 Aug 1:39:101-105.
doi: 10.1016/j.jdcr.2023.07.025. eCollection 2023 Sep.

A diagnostic challenge: Life-threatening drug reaction with eosinophilia and systemic symptoms in the setting of a SARS-CoV-2 and human herpesvirus-6 reactivation in a patient with severe hepatic injury on bupropion

Djoni Elkady  1 , Chiamaka L Okorie  2 , Blanca Estupiñan  3 , Mitul B Modi  4 , Scott J Cotler  5 , Eden Lake  3
Affiliations
Case Reports

A diagnostic challenge: Life-threatening drug reaction with eosinophilia and systemic symptoms in the setting of a SARS-CoV-2 and human herpesvirus-6 reactivation in a patient with severe hepatic injury on bupropion

Djoni Elkady et al. JAAD Case Rep. .
No abstract available

Keywords: COVID; DILI; DRESS; SARS-CoV-2; bupropion; drug reaction; drug-induced; hypersensitivity syndrome.

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Conflict of interest statement

None.

Figures

Fig 1
Fig 1
Patient with a diffuse morbilliform rash involving the face with edema (A), arms, trunk, back, and legs (B).
Fig 2
Fig 2
(A) 200-um scanning magnification of hematoxylin and eosin skin biopsy demonstrating basket-weave orthokeratosis with interface dermatitis and vacuolar interface changes, (B) superficial perivascular and interstitial mixed inflammation with lymphocytes as well as scattered neutrophils and eosinophils, associated scattered apoptotic keratinocytes, (C) 50-um scanning magnification of hematoxylin and eosin liver biopsy demonstrating lobular injury with hepatocyte swelling and numerous acidophilic bodies, (D) mixed inflammation with predominant small mature lymphocyte, rare plasma cell (black arrow) and eosinophil (red arrow) infiltrates as well as focal interface activity, and (E) perivenulitis.
See this image and copyright information in PMC

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