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. 2023 Aug 11:14:1234040.
doi: 10.3389/fgene.2023.1234040. eCollection 2023.

Prognostic effect of lncRNA BBOX1-AS1 in malignancies: a meta-analysis

Guangyao Lin  1 , Yongzhou Wang  2 , Li Deng  2 , Tao Ye  2
Affiliations

Prognostic effect of lncRNA BBOX1-AS1 in malignancies: a meta-analysis

Guangyao Lin et al. Front Genet. .

Abstract

Background: With the increasing number of new cancer cases and mortality rates, cancer has become a serious global health problem, but there are no ideal cancer biomarkers for effective diagnosis. Currently, mounting evidence demonstrates that lncRNAs play a fundamental role in cancer progression. BBOX1 anti-sense RNA 1 (BBOX1-AS1) is a recently clarified lncRNA and has been identified as dysregulated in various carcinomas, and it contributes to poor survival in cancer patients. Methods: We thoroughly searched six databases for eligible articles published as of 27, April 2023. The association of BBOX1-AS1 expression levels with prognostic and clinicopathological parameters was assessed by odds ratios (OR) and hazard ratios with 95% CIs. Additionally, we further validated our results utilizing the GEPIA online database. Results: Eight studies comprising 602 patients were included in this analysis. High BBOX1-AS1 expression indicated poor overall survival (OS) (hazard ratios = 2.30, 95% Cl [1.99, 2.67], p < 0.00001) when compared with low BBOX1-AS1 expression. Furthermore, BBOX1-AS1 expression was positively correlated with lymph node metastasis (OR = 3.00, 95% CI [1.71-5.28], p = 0.0001) and advanced tumor stage (OR = 3.74, 95% CI [2.63-5.32], p < 0.00001) for cancer patients. Moreover, BBOX1-AS1 was remarkably upregulated in 12 malignancies, and the elevated BBOX1-AS1 expression predicted poorer OS and worse disease-free survival (DFS) confirmed through the GEPIA online gene analysis tool. Conclusion: The findings highlight that BBOX1-AS1 was significantly associated with detrimental overall survival, disease-free survival, lymph node metastasis and tumor stage; thus, it could act as a novel promising biomarker to predict the clinicopathological characteristics and prognosis for various cancers.

Keywords: human malignancies; lncRNA BBOX1-AS; meta-analysis; prognosis; review.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Article selection flowchart.
FIGURE 2
FIGURE 2
Forest plots assessing the association between BBOX1-AS1 expression and clinicopathological parameters [(A) lymph node metastasis, (B) stage, (C) differentiation, (D) gender, (E) age, and (F) tumor size].
FIGURE 3
FIGURE 3
Forest plot for the association between BBOX1-AS1 expression with OS.
FIGURE 4
FIGURE 4
BBOX1-AS1 expression in 12 types of tumor tissues (red) vs. normal tissues (blue). “*” p < 0.01. Abbreviations: T, tumor tissues; N, normal tissues; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; COAD, colon adenocarcinoma; ESCA, esophageal carcinoma; HNSC, head and neck squamous cell carcinoma; LUSC, lung squamous cell carcinoma; OV, ovarian serous cystadenocarcinoma; READ, rectum adenocarcinoma; STAD, stomach adenocarcinoma; THYM, thymoma, UCEC, uterine corpus endometrial carcinoma; UCS, uterine carcinosarcoma; TGCT, testicular germ cell tumors.
FIGURE 5
FIGURE 5
Verification of the prognostic value of BBOX1-AS1 in the TCGA database. (A) OS plots of BBOX1-AS1 in LGG, (B) OS plots of BBOX1-AS1 in MESO, (C) OS plots of BBOX1-AS1 in BRCA, (D) DFS plots of BBOX1-AS1 in LGG, (E) DFS plots of BBOX1-AS1 in MESO, and (F) DFS plots of BBOX1-AS1 in SARC. Abbreviations: TCGA, The Cancer Genome Atlas; LGG, brain lower grade glioma; MESO, mesothelioma; BRCA, breast invasive carcinoma; SARC, sarcoma.
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