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. 2023 Sep;75(3):1336-1343.
doi: 10.1007/s12070-023-03562-2. Epub 2023 Feb 13.

Incidence of Post Total Laryngectomy Hypothyroidism: Effects of Thyroid Gland Surgery and Post-Operative Radiotherapy

Ahmed Amin Nassar  1 , Abdelrahman Ahmed Shoaib  1 , Hazem Mohammed Dewidar  1 , Khaled Omar Azooz  1
Affiliations

Incidence of Post Total Laryngectomy Hypothyroidism: Effects of Thyroid Gland Surgery and Post-Operative Radiotherapy

Ahmed Amin Nassar et al. Indian J Otolaryngol Head Neck Surg. 2023 Sep.

Abstract

To record the incidence of hypothyroidism in patients after total laryngectomy, whether with or without postoperative radiation therapy and to analyze the effect of hemithyroidectomy for the development of hypothyroidism. A retrospective study included patients who underwent total laryngectomy (with or without hemithyroidectomy) between 2018 and 2021 for laryngeal carcinoma and/or received postoperative radiotherapy. Thirty-six (45%) of the 80 enrolled patients developed hypothyroidism after a median follow-up of 16 months. In this study, adjuvant radiation and central neck dissection were found to be significantly linked with developing post-operative hypothyroidism (p values: 0.001, 0.007, respectively). The incidence of hypothyroidism in patients treated for laryngeal carcinoma is high, especially after combination treatment of surgery and radiotherapy.

Keywords: Hypothyroidism; Radiotherapy; Thyroidectomy; Total laryngectomy.

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Conflict of interest statement

Conflict of interestAll authors declare that they have no conflict of intersets.

Figures

Fig. 1
Fig. 1
Box plots of interval between TL and development of hypothyroidism in 80 patients in relation to the four treatment regimens
Fig. 2
Fig. 2
A, Cumulative euthyroid survival of all TL patients. B, Cumulative euthyroid survival stratified for treatment regimen
Fig. 3
Fig. 3
Postoperative thyroid gland surveillance in relation to thyroid gland surgery
Fig. 4
Fig. 4
Schematic overview of the number of patients who developed hypothyroidism in relation to both thyroid gland surgery and treatment regimen
See this image and copyright information in PMC

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