Kimura Disease-A Case Report

Abstract

Kimura Disease, an eosinophilic hyperplastic granulomatous disease of idiopathic origin is most commonly seen in young males. It mostly presents with deep subcutaneous tissue swelling along with enlargement of salivary glands and regional lymphadenopathy. Diagnosis is mainly based on histopathological findings and raised serum IgE and hypereosinophilia. The radiological investigation of choice is Magnetic Resonance Imaging. Management strategy includes surgery and steroid therapy. Chemotherapeutic agents are also frequently used by some centres. Relapse and recurrence stands to be a common problem with management of this disease process.

Supplementary information: The online version contains supplementary material available at 10.1007/s12070-023-03817-y.

Keywords: Angiolymphatic proliferation; Eosinophilic microabscess; Hypereosinophilia; Kimura Disease; Raised serum IgE.

Fig. 1

A: Preoperative image of patient with large left face swelling, B: Pre operative MRI image (T2)showing heterogeneously hyperintense soft tissue lesion with internal flow voids on the left face

Fig. 2

A: Excisional specimen, B: excisional specimen

Fig. 3

A: Histopathology showing a hyperplastic follicle with germinal centre (H &E, 200x), B: High power showing expansion of interfollicular region by eosinophils forming eosinophilic microabscess (H &E, 400x)