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. 2023 Sep;75(3):1625-1630.
doi: 10.1007/s12070-023-03706-4. Epub 2023 Mar 22.

Comparative Survival Function in Patients with Positive Surgical Margins Following Laryngectomy

Yılmaz Özkul  1 , Ejder Ciğer  2 , Mustafa Koray Balcı  3 , Ahmet Erdem Kılavuz  4 , Feda Bayrak  1 , Murat Songu  1 , Akif İşlek  5   6
Affiliations

Comparative Survival Function in Patients with Positive Surgical Margins Following Laryngectomy

Yılmaz Özkul et al. Indian J Otolaryngol Head Neck Surg. 2023 Sep.

Abstract

Aims: This study aims to make a comparative analysis of disease-free survival (DFS) and overall disease-specific survival (OS) in patients with laryngeal carcinoma. Materials and methods: The study was designed retrospectively. Sixteen patients with postoperative PSM and 30 with negative surgical margins (NSM) were included. Survival analysis and Long-Rank comparisons was performed for DFS and OS between groups. Results: PSM was a significant independent risk factor for loco-regional recurrence and disease-related mortality (p = 0.004, HR: 1.6, p = 0.002, HR: 3.2, respectively). DFS and OS were significantly longer in NSM group (p = 0.001 and 0.003, respectively). For PSM group, 2- and 5-year DFS rates were 57%; OS rates were 80% and 34% respectively. In NSM group, 2- and 5-year DFS rates were 96% and 83%; OS rates were found to be 96%. Conclusion: PSM had significant relation with poor prognosis.

Keywords: Laryngeal carcinoma; Prognosis; Recurrence; Surgical margin; Survival.

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Conflict of interest statement

Conflict of interestNone.

Figures

Fig. 1
Fig. 1
Kaplan Meier graph of disease-free survival (DFS) according to study groups
Fig. 2
Fig. 2
Kaplan Meier graph of disease-specific overall survival (OS) according to study groups
See this image and copyright information in PMC

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