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. 2023 Nov;70(11):e30642.
doi: 10.1002/pbc.30642. Epub 2023 Aug 28.

18 F-FDG-PET/CT imaging in diagnostic workup of pediatric precursor B-cell lymphoblastic lymphoma

Emma Kroeze  1 , Laura Arias Padilla  2 , Birgit Burkhardt  2 , Andishe Attarbaschi  3   4 , Hannah von Mersi  3 , Rejin Kebudi  5 , Rutger A J Nievelstein  1   6 , Nelleke Tolboom  1   6 , Melanie M Hagleitner  1 , Roland P Kuiper  1   7 , Auke Beishuizen  1   8 , Jan L C Loeffen  1
Affiliations

18 F-FDG-PET/CT imaging in diagnostic workup of pediatric precursor B-cell lymphoblastic lymphoma

Emma Kroeze et al. Pediatr Blood Cancer. 2023 Nov.

Abstract

18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) imaging is currently not used in standard diagnostics for B-cell precursor lymphoblastic lymphoma (BCP-LBL), and it is unknown whether PET/CT imaging would lead to agreement between detection of lesions with the gold standard imaging methods. Therefore, we performed a retrospective cohort study in which we included 32 pediatric BCP-LBL patients and determined localizations by reviewing local imaging reports. There was a disagreement between protocol-based imaging and PET/CT in 59% of the patients, and the discrepancies mostly comprise of additional lesions detected with PET/CT, typically in lymph node and bone or the absence of bone marrow involvement with PET/CT. If PET/CT was leading in determining definite stage of disease, this would lead to a different stage and therapy branch in 31% and 28% of the patients, respectively.

Keywords: 18F-FDG-PET/CT; B-cell; PET/CT; diagnostics; imaging; lymphoblastic lymphoma; non-Hodgkin lymphoma.

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REFERENCES

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