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Review
. 2023 Oct 1;36(5):382-387.
doi: 10.1097/WCO.0000000000001200. Epub 2023 Aug 17.

A patient with neuropathy and ataxia: what do I have to consider?

Leslie J Roberts  1 , David J Szmulewicz  2   3
Affiliations
Review

A patient with neuropathy and ataxia: what do I have to consider?

Leslie J Roberts et al. Curr Opin Neurol. .

Abstract

Purpose of review: An increasing number of peripheral neuro(no)pathies are identified as involving other components of the neurological system, particularly those that further impair balance. Here we aim to outline an evidence-based approach to the diagnosis of patients who present with a somatosensory disorder which also involves at least one other area of neurological impairment such as the vestibular, auditory, or cerebellar systems.

Recent findings: Detailed objective investigation of patients who present with sensory impairment, particularly where the degree of imbalance is greater than would be expected, aids the accurate diagnosis of genetic, autoimmune, metabolic, and toxic neurological disease.

Summary: Diagnosis and management of complex somatosensory disorders benefit from investigation which extends beyond the presenting sensory impairment.

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References

    1. Lehmann HC, Wunderlich G, Fink GR, Sommer C. Diagnosis of peripheral neuropathy. Neurological Res Pract 2020; 2:20.
    1. Upadhyaya V, Choudur HN. Imaging in peripheral neuropathy: Ultrasound and MRI. Indian J Musculoskelet Radiol 2021; 3:14–23.
    1. Roberts LJ, McVeigh M, Seiderer L, et al. Overview of the clinical approach to individuals with cerebellar ataxia and neuropathy. Neurol Genet 2022; 8:e200021.
    1. Szmulewicz DJ, Seiderer L, Halmagyi GM, et al. Neurophysiological evidence for generalized sensory neuronopathy in cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome. Muscle Nerve [Internet] 2015; 51:600–603.
    1. Wuehr M, Schniepp R, Schlick C, et al. Sensory loss and walking speed related factors for gait alterations in patients with peripheral neuropathy. Gait Posture 2014; 39:852–858.