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. 2023 Nov;34(11):691-693.
doi: 10.1016/j.tem.2023.08.003. Epub 2023 Aug 26.

The obese brain: is it a matter of time?

Ambica Bora  1 , Alexandre Fisette  2
Affiliations

The obese brain: is it a matter of time?

Ambica Bora et al. Trends Endocrinol Metab. 2023 Nov.

Abstract

Understanding how obesity rewires the brain, triggers neuroinflammation and neurodegeneration relies on research using animal models. There is, however, a disconnect between the timeline of human obesity and typical preclinical protocols. We emphasize here the need to adopt models of chronic obesity to study the pathophysiology of human obesity.

Keywords: dopamine; hypothalamus; leptin; melanocortin; mouse models; obesity.

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Conflict of interest statement

Declaration of interests No interests are declared.

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