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Comment
. 2023 Oct;24(10):1639-1641.
doi: 10.1038/s41590-023-01602-1. Epub 2023 Aug 28.

The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function

Chrysante S Iliakis  1 , Justina Kulikauskaite  1 , Helena Aegerter  2   3 , Fengqi Li  4 , Federica Piattini  4 , Claudia V Jakubzick  5 , Martin Guilliams  6   7 , Manfred Kopf  4 , Andreas Wack  8
Affiliations
Comment

The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function

Chrysante S Iliakis et al. Nat Immunol. 2023 Oct.
No abstract available

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Conflict of interest statement

Competing interests

The authors declare no competing interests.

Figures

Fig. 1 |
Fig. 1 |. Recruitment versus training of the alveolar macrophage compartment.
a, One month after influenza infection, fetal monocyte-derived AMs (FeMoAMs, blue) as well as bone marrow monocyte-derived AMs (BMoAMs, red) developing during infection are present and might appear similar based on expression of general macrophage markers, such as CD64, MerTK and CD11c. b, Apparent training of the AM compartment. Using CD11c-positive selection for functional analysis, the AM compartment might appear to be trained due to elevated immunoreactivity contributed by BMoAMs. c, Detection of immunoreactive BMoAMs in functional assays. Using Siglec-F expression, congenic markers in bone marrow chimeric mice or lineage tracing approaches, FeMoAMs and BMoAMs can be functionally distinguished. Created with https://biorender.com.
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References

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