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Comparative Study
. 2023 Aug 1;24(8):2615-2619.
doi: 10.31557/APJCP.2023.24.8.2615.

Agreement between Self- and Physician‑Sampling for Detection of High‑Risk Human Papillomavirus Infections in Women Attending Cervical Screening at National Cancer Institute, Thailand

Suleeporn Sangrajrang  1 , Supakorn Pitakkarnkul  2 , Richard Muwonge  3 , Pattama Ploysawang  1 , Parinda Pangmuang  1 , Kanda Seeda  1 , Partha Basu  3
Affiliations
Comparative Study

Agreement between Self- and Physician‑Sampling for Detection of High‑Risk Human Papillomavirus Infections in Women Attending Cervical Screening at National Cancer Institute, Thailand

Suleeporn Sangrajrang et al. Asian Pac J Cancer Prev. .

Abstract

Background: We determined testing of self-sampling vagina swabs for Human Papilloma Virus (HPV) can be used to screen for cervical disease in outpatient clinics.

Methods: In this study, women attending cervical cancer screening clinic and gynecology clinic of the National Cancer Institute were invited to take a vaginal self-sampling and physician-collected cervical sampling.

Results: Of 268 participants, 20 (7.5%) were HPV-positive on the physician-collected samples. Among these screen-positive women, only two (0.7%) had HPV 18 and/or 45 and none had HPV 16 infections. For the self-collected samples, 4 participants had invalid HPV test results. Of the remaining 264 women with valid test results on self-collected samples, 29 (11.0 %) were HPV-positive, of whom, two (0.8%) were infected with HPV 16 and one (0.4%) with HPV 18 and/or 45 infections. The agreement between self-sampling and physician-sampling HPV test results (when two HPV results categories were considered) was 92. 8% with a moderate Kappa value of 0.57.

Conclusion: Overall, self-sampling seems to be a reliable alternative to health-provider collection. However, instructions on proper procedures for sample collection to the women are important step before general roll out.

Keywords: HPV DNA test; National Cancer Institute; Self‑sampling; Thailand; cervical cancer screening.

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Conflict of interest statement

The authors declare that they have no competing interests.

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References

    1. Arbyn M, Smith SB, Temin S, et al. Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses. BMJ. 2018;363:k4823. - PMC - PubMed
    1. Arbyn M, Simon M, de Sanjosé S, et al. Accuracy and effectiveness of HPV mRNA testing in cervical cancer screening: a systematic review and meta-analysis. Lancet Oncol. 2022;23:950–60. - PubMed
    1. Bhatla N, Dar L, Patro AR, et al. Can human papillomavirus DNA testing of self-collected vaginal samples compare with physician-collected cervical samples and cytology for cervical cancer screening in developing countries? Cancer Epidemiol. 2009;33:446–50. - PMC - PubMed
    1. Boggan JC, Walmer DK, Henderson G, et al. Vaginal Self-Sampling for Human Papillomavirus Infection as a Primary Cervical Cancer Screening Tool in a Haitian Population. Sex Transm Dis. 2015;42:655–9. - PMC - PubMed
    1. Castle PE, Gage JC, Partridge EE, Rausa A, Gravitt PE, Scarinci IC. Human papillomavirus genotypes detected in clinician-collected and self-collected specimens from women living in the Mississippi Delta. BMC Infect Dis. 2013;13:5. - PMC - PubMed

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