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. 2023 Nov;28(11):1060-1068.
doi: 10.1111/resp.14581. Epub 2023 Aug 29.

Factors associated with failure of cardiopulmonary function recovery after lung cancer surgery

Sunga Kong  1   2 , Sumin Shin  3 , Yeong Jeong Jeon  4 , Genehee Lee  1   2 , Jong Ho Cho  4 , Hong Kwan Kim  4 , Young Mog Shim  1   4 , Juhee Cho  1   2   5   6 , Danbee Kang  2   5 , Hye Yun Park  7
Affiliations

Factors associated with failure of cardiopulmonary function recovery after lung cancer surgery

Sunga Kong et al. Respirology. 2023 Nov.

Abstract

Background and objective: This study aimed to evaluate the longitudinal changes in cardiopulmonary function (CPF) and identify predictors of cardiopulmonary recovery failure after lung cancer surgery.

Methods: Data was obtained from a prospective CATCH-LUNG cohort study, where patients were divided into two groups based on 6-min walk distance (6MWD) at baseline and 6 months after surgery. CPF recovery failure was defined as a participant whose 6MWD dropped over 50 m from baseline to 6 months after surgery. Patients with a baseline 6MWD less than 400 m were excluded. The analysis was investigated using mixed effects models, and the relative estimates for the predictors were expressed relative risk (RR) and 95% CI using a Poisson regression.

Results: Among 419 patients, 24.1% and 17.7% showed failure of CPF recovery at 6 months and 1 year after surgery, respectively. In the multivariable analysis, baseline step count [RR per 1000 steps lower = 1.05 (95% CI, 1.01-1.09)], baseline dyspnoea [RR per 10 points higher = 1.15(1.07-1.23)], decreased FEV1 % predicted from baseline to 2 weeks after surgery [RR per 10% lower = 1.30(1.10-1.53)] and decreased moderate-to-vigorous physical activity (MVPA) from baseline to 2 weeks [RR = 1.95(1.22, 3.11)] or persistent low MVPA at baseline and 2 weeks after surgery [RR = 1.63(1.04, 2.54)] were significant factors for loss of CPF.

Conclusion: The inability to recover CPF at 6 months after surgery was linked to reduction of lung function and MVPA from baseline to 2 weeks as well as baseline physical activity (PA) and dyspnoea. These results imply that engagement of perioperative PA is necessary to facilitate recovery of CPF after lung cancer surgery.

Trial registration: ClinicalTrials.gov NCT03705546.

Keywords: cardiopulmonary function; lung cancer; patients reported outcomes; physical activity; pulmonary function; surgery.

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References

REFERENCES

    1. Howington JA, Blum MG, Chang AC, Balekian AA, Murthy SC. Treatment of stage I and II non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143:e278S-e313S.
    1. Goldstraw P, Chansky K, Crowley J, Rami-Porta R, Asamura H, Eberhardt WE, et al. The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer. J Thorac Oncol. 2016;11:39-51.
    1. Shin S, Kong S, Kang D, Lee G, Cho JH, Shim YM, et al. Longitudinal changes in pulmonary function and patient-reported outcomes after lung cancer surgery. Respir Res. 2022;23:224.
    1. Gu Z, Wang H, Mao T, Ji C, Xiang Y, Zhu Y, et al. Pulmonary function changes after different extent of pulmonary resection under video-assisted thoracic surgery. J Thorac Dis. 2018;10:2331-2337.
    1. Zhou W, Webster KE, Smith EL, Chen W, Veliz PT, Reddy RM, et al. Physical activity in surgical lung cancer patients: a systematic review. Support Care Cancer. 2022;30:6473-6482.

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