Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Oct;483(4):441-449.
doi: 10.1007/s00428-023-03630-6. Epub 2023 Aug 29.

Predictive value of tumor budding in head and neck squamous cell carcinoma: an update

Carlos M Chiesa-Estomba  1   2 , Lester Thompson  3 , Abbas Agaimy  4 , Nina Zidar  5 , Roderick H W Simpson  6 , Alessandro Franchi  7 , Juan P Rodrigo  8 , Antti A Mäkitie  9 , Alhadi Almangush  10   11 , Ilmo Leivo  12 , Alfio Ferlito  13
Affiliations
Review

Predictive value of tumor budding in head and neck squamous cell carcinoma: an update

Carlos M Chiesa-Estomba et al. Virchows Arch. 2023 Oct.

Abstract

Head and neck squamous cell carcinoma forms an anatomically and functionally complex group of malignancies. The significant local aggressiveness and frequent regional relapses motivate ongoing research to identify more reliable and sensitive prognostic and predictive biomarkers. One emerging area of cancer biology is the evaluation of tumor budding at the advancing invasive front of various types of epithelial cancers. Recent studies suggest that tumor budding is a relatively common phenomenon in cancer progression and that it may have important prognostic implications for patients due to its potential to provide valuable insights into the biology and clinical behavior of head and neck cancer. In this review, we aim to provide information about tumor budding in head and neck squamous cell carcinoma. Thus, we hope to shed light on the complex biology of these malignancies, as well as aiding diagnostic, classification, and better characterization and thereby, looking for new avenues for improving patient outcomes.

Keywords: Budding; Cancer; Head; Neck; Tumor.

PubMed Disclaimer

References

    1. Braakhuis BJ, Leemans CR, Visser O (2014) Incidence and survival trends of head and neck squamous cell carcinoma in the Netherlands between 1989 and 2011. Oral Oncol 50:670–675. https://doi.org/10.1016/j.oraloncology.2014.03.008 - DOI - PubMed
    1. Wagner S, Sharma SJ, Wuerdemann N et al (2017) Human papillomavirus-related head and neck cancer. Oncol Res Treat 40:334–340. https://doi.org/10.1159/000477252 - DOI - PubMed
    1. Gath HJ, Brakenhoff RH (1999) Minimal residual disease in head and neck cancer. Cancer Metastasis Rev 18:109–126. https://doi.org/10.1023/a:1006268621730 - DOI - PubMed
    1. Okuyama K, Suzuki K, Yanamoto S (2023) Relationship between tumor budding and partial epithelial-mesenchymal transition in head and neck cancer. Cancers (Basel) 15:1111. https://doi.org/10.3390/cancers15041111 - DOI - PubMed
    1. Ueno H, Murphy J, Jass JR, Mochizuki H, Talbot IC (2002) Tumour budding as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology 40:127–132. https://doi.org/10.1046/j.1365-2559.2002.01324.x - DOI - PubMed

Substances

LinkOut - more resources