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. 2023 Aug 29;75(1):75.
doi: 10.1186/s43044-023-00401-1.

Effect of body mass index on N-terminal pro-brain natriuretic peptide values in patients with heart failure

Tuan Ha Manh  1 , Duong Do Anh  2 , Tung Le Viet  3   4
Affiliations

Effect of body mass index on N-terminal pro-brain natriuretic peptide values in patients with heart failure

Tuan Ha Manh et al. Egypt Heart J. .

Abstract

Background: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a biomarker used for the diagnosis of heart failure. There is a relationship between NT-proBNP levels and body mass index (BMI). The study aimed to explore the impact of BMI on NT-proBNP concentrations and to examine whether other factors independent of or combined with BMI affect NT-proBNP values in patients with heart failure.

Results: A total of 293 participants were recruited. The mean age was 68.9 ± 13.2 years, males accounted for 46.4% of the total cohort, the mean BMI was 23.1 ± 4.0 kg/m2, and the median NT-proBNP level was 3776 (1672-8806) pg/ml. There was an inverse relationship between BMI and log NT-proBNP (r = - 0.29; p < 0.001, Spearman correlation). Each standard deviation increase in BMI (4 kg/m2) was associated with a 7% decrease in NT-proBNP values in the total cohort. The independent inverse determinants of NT-proBNP other than BMI were male gender and eGFR, while the variables directly correlated to NT-proBNP were LVEF ≤ 40% and NYHA class III-IV heart failure.

Conclusions: There is an inverse association between BMI and NT-proBNP levels. However, the correlation is weak, and there are other variables that have a significant impact on the NT-proBNP values as well. The NT-proBNP levels are still valuable in the diagnosis of heart failure regardless of BMI status.

Keywords: Body mass index (BMI); Heart failure; N-terminal pro-B-type natriuretic peptide (NT-proBNP); Obesity.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Box plots show median NT-proBNP values in lean, overweight, and obese heart failure patients
Fig. 2
Fig. 2
Correlation between log NT-proBNP values with body mass index (BMI)
Fig. 3
Fig. 3
Correlation between log NT-proBNP values with body mass index (BMI) in male
See this image and copyright information in PMC

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