Metabolomics of head and neck cancer in biofluids: an integrative systematic review

Natalia Chuchueva^{1

2}, Filippo Carta³, Hoang N Nguyen¹, Jennifer Luevano⁴, Isaiah A Lewis⁴, Israel Rios-Castillo⁵, Vassilios Fanos⁶, Emma King^{7

8}, Valery Swistushkin¹, Igor Reshetov¹, Yury Rusetsky^{2

9}, Ksenia Shestakova^{10

11}, Natalia Moskaleva^{10

11}, Cinzia Mariani³, Alvaro Castillo-Carniglia^{12

13}, Dmitry Grapov¹⁴, Johannes Fahrmann¹⁵, Michael R La Frano^{4

16

17}, Roberto Puxeddu^{18

19}, Svetlana A Appolonova^{10

20}, Alex Brito^{21

22}

Affiliations

¹ I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
² Central State Medical Academy, Moscow, Russia.
³ Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria Di Cagliari, University of Cagliari, Cagliari, Italy.
⁴ Department of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, CA, USA.
⁵ Medical School, University of Panama, Panama City, Panama.
⁶ Department of Pediatrics and Clinical Medicine, Section of Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliero-Universitaria Di Cagliari, Cagliari University, Cagliari, Italy.
⁷ Cancer Research Center, University of Southampton, Southampton, UK.
⁸ Department of Otolaryngology, Poole Hospital National Health Service Foundation Trust, Longfleet Road, Poole, UK.
⁹ Otorhinolaryngological Surgical Department With a Group of Head and Neck Diseases, National Medical Research Center of Children's Health, Moscow, Russia.
¹⁰ Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology. I.M. Sechenov First, Moscow State Medical University, Moscow, Russia.
¹¹ World-Class Research Center "Digital Biodesign and Personalized Healthcare", I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
¹² Society and Health Research Center, Facultad de Ciencias Sociales y Artes, Universidad Mayor, Santiago, Chile.
¹³ Millennium Nucleus for the Evaluation and Analysis of Drug Policies (nDP) and Millennium Nucleus on Sociomedicine (SocioMed), Santiago, Chile.
¹⁴ CDS-Creative Data Solutions, Colfax, CA, USA.
¹⁵ MD Anderson Cancer Center, Houston, TX, USA.
¹⁶ Cal Poly Metabolomics Service Center, California Polytechnic State University, San Luis Obispo, CA, USA.
¹⁷ Roy J.Carver Metabolomics Core Facility, University of Illinois, Urbana-Champaign, IL, USA.
¹⁸ King's College Hospital London, Dubai, United Arab Emirates.
¹⁹ Section of Otorhinolaryngology, Department of Surgery, University of Cagliari, Cagliari, Italy.
²⁰ Russian Center of Forensic-Medical Expertise of Ministry of Health, Moscow, Russia.
²¹ Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology. I.M. Sechenov First, Moscow State Medical University, Moscow, Russia. abrito@micronutriomics.com.
²² World-Class Research Center "Digital Biodesign and Personalized Healthcare", I.M. Sechenov First Moscow State Medical University, Moscow, Russia. abrito@micronutriomics.com.

PMID: 37644353
DOI: 10.1007/s11306-023-02038-2

Metabolomics of head and neck cancer in biofluids: an integrative systematic review

Natalia Chuchueva et al. Metabolomics. 2023.

. 2023 Aug 29;19(9):77.

doi: 10.1007/s11306-023-02038-2.

Authors

Affiliations

¹ I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
² Central State Medical Academy, Moscow, Russia.
³ Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria Di Cagliari, University of Cagliari, Cagliari, Italy.
⁴ Department of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, CA, USA.
⁵ Medical School, University of Panama, Panama City, Panama.
⁶ Department of Pediatrics and Clinical Medicine, Section of Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliero-Universitaria Di Cagliari, Cagliari University, Cagliari, Italy.
⁷ Cancer Research Center, University of Southampton, Southampton, UK.
⁸ Department of Otolaryngology, Poole Hospital National Health Service Foundation Trust, Longfleet Road, Poole, UK.
⁹ Otorhinolaryngological Surgical Department With a Group of Head and Neck Diseases, National Medical Research Center of Children's Health, Moscow, Russia.
¹⁰ Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology. I.M. Sechenov First, Moscow State Medical University, Moscow, Russia.
¹¹ World-Class Research Center "Digital Biodesign and Personalized Healthcare", I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
¹² Society and Health Research Center, Facultad de Ciencias Sociales y Artes, Universidad Mayor, Santiago, Chile.
¹³ Millennium Nucleus for the Evaluation and Analysis of Drug Policies (nDP) and Millennium Nucleus on Sociomedicine (SocioMed), Santiago, Chile.
¹⁴ CDS-Creative Data Solutions, Colfax, CA, USA.
¹⁵ MD Anderson Cancer Center, Houston, TX, USA.
¹⁶ Cal Poly Metabolomics Service Center, California Polytechnic State University, San Luis Obispo, CA, USA.
¹⁷ Roy J.Carver Metabolomics Core Facility, University of Illinois, Urbana-Champaign, IL, USA.
¹⁸ King's College Hospital London, Dubai, United Arab Emirates.
¹⁹ Section of Otorhinolaryngology, Department of Surgery, University of Cagliari, Cagliari, Italy.
²⁰ Russian Center of Forensic-Medical Expertise of Ministry of Health, Moscow, Russia.
²¹ Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology. I.M. Sechenov First, Moscow State Medical University, Moscow, Russia. abrito@micronutriomics.com.
²² World-Class Research Center "Digital Biodesign and Personalized Healthcare", I.M. Sechenov First Moscow State Medical University, Moscow, Russia. abrito@micronutriomics.com.

PMID: 37644353
DOI: 10.1007/s11306-023-02038-2

Abstract

Introduction: Head and neck cancer (HNC) is the fifth most common cancer globally. Diagnosis at early stages are critical to reduce mortality and improve functional and esthetic outcomes associated with HNC. Metabolomics is a promising approach for discovery of biomarkers and metabolic pathways for risk assessment and early detection of HNC.

Objectives: To summarize and consolidate the available evidence on metabolomics and HNC in plasma/serum, saliva, and urine.

Methods: A systematic search of experimental research was executed using PubMed and Web of Science. Available data on areas under the curve was extracted. Metabolic pathway enrichment analysis were performed to identify metabolic pathways altered in HNC. Fifty-four studies were eligible for data extraction (33 performed in plasma/serum, 15 in saliva and 6 in urine).

Results: Metabolites with high discriminatory performance for detection of HNC included single metabolites and combination panels of several lysoPCs, pyroglutamate, glutamic acid, glucose, tartronic acid, arachidonic acid, norvaline, linoleic acid, propionate, acetone, acetate, choline, glutamate and others. The glucose-alanine cycle and the urea cycle were the most altered pathways in HNC, among other pathways (i.e. gluconeogenesis, glycine and serine metabolism, alanine metabolism, etc.). Specific metabolites that can potentially serve as complementary less- or non-invasive biomarkers, as well as metabolic pathways integrating the data from the available studies, are presented.

Conclusion: The present work highlights utility of metabolite-based biomarkers for risk assessment, early detection, and prognostication of HNC, as well as facilitates incorporation of available metabolomics studies into multi-omics data integration and big data analytics for personalized health.

Keywords: Big data; Biomarkers; Head and neck cancer; Malignancies; Metabolites; Metabolome; Metabolomics; Omics; Oncology; Personalized health; Squamous cell carcinoma.

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Metabolomics of head and neck cancer in biofluids: an integrative systematic review

Affiliations

Metabolomics of head and neck cancer in biofluids: an integrative systematic review

Authors

Affiliations

Abstract

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LinkOut - more resources

Medical