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Review
. 2023 Aug 3;60(3):271-282.
doi: 10.29399/npa.28203. eCollection 2023.

Memory Impairing Effect of Propranolol on Consolidation and Reconsolidation for Various Learning Tasks

Çınar Furkan İlhan  1 , Sezen Kışlal  1
Affiliations
Review

Memory Impairing Effect of Propranolol on Consolidation and Reconsolidation for Various Learning Tasks

Çınar Furkan İlhan et al. Noro Psikiyatr Ars. .

Abstract

Newly acquired memory traces have been thought to become stable and resistant to interruption after they are stored in long-term memory. However, according to a recent research drugs such as beta-adrenergic receptor antagonists enable memories to be updated and rewritten when administered during consolidation and reconsolidation. Propranolol is a widely used beta-adrenergic receptor antagonist that disrupts the consolidation and reconsolidation processes of memory formation as it inhibits protein synthesis in the central nervous system. This review aims to discuss the memory impairing effect of the systemic and intracerebral administration of propranolol during the consolidation and reconsolidation processes associated with different learning tasks. In doing so, this review will help elucidate the effects of propranolol on different stages of memory formation. Since learning and maladaptive memories underpin some of the most common psychological disorders, such as phobias, post-traumatic stress disorder, addiction, drug-seeking behavior, and so on, a thorough understanding of propranolol's memory-impairing effect has significant clinical value and the potential to help people suffering from these disorders.

Keywords: Memory; consolidation; propranolol; reconsolidation; rodent.

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Conflict of interest statement

Conflict of Interest: The authors declared that there is no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram.
See this image and copyright information in PMC

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