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Review
. 2023 Aug 14:14:1226443.
doi: 10.3389/fimmu.2023.1226443. eCollection 2023.

Function of reactive oxygen species in myeloid-derived suppressor cells

Jiaojiao Huang  1 , Yue Zhao  1 , Kexin Zhao  1 , Kai Yin  2 , Shengjun Wang  1   3
Affiliations
Review

Function of reactive oxygen species in myeloid-derived suppressor cells

Jiaojiao Huang et al. Front Immunol. .

Abstract

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous myeloid cell population and serve as a vital contributor to the tumor microenvironment. Reactive oxygen species (ROS) are byproducts of aerobic respiration and are involved in regulating normal biological activities and disease progression. MDSCs can produce ROS to fulfill their immunosuppressive activity and eliminate excessive ROS to survive comfily through the redox system. This review focuses on how MDSCs survive and function in high levels of ROS and summarizes immunotherapy targeting ROS in MDSCs. The distinctive role of ROS in MDSCs will inspire us to widely apply the blocked oxidative stress strategy in targeting MDSC therapy to future clinical therapeutics.

Keywords: MDSCs; ROS; immunotherapy; tumor; tumor micro environment (TME).

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Regulation of ROS in MDSCs.
Figure 2
Figure 2
Regulation of other cells by MDSC-derived ROS.
See this image and copyright information in PMC

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