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. 2023 Oct 1;93(4):727-730.
doi: 10.1227/neu.0000000000002634. Epub 2023 Aug 30.

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for Patients With Chiari Malformation: Symptoms

Eric M Jackson  1 , Sarah Jernigan  2 , Jeffrey S Raskin  3 , Laurie L Ackerman  4 , Libby Kosnik Infinger  5 , Cormac O Maher  6 , Toba Niazi  7 , Jogi V Pattisapu  8 , Rabia Qaiser  9 , Carolyn Quinsey  10 , Brandon G Rocque  11 , Howard Silberstein  12 , Shobhan Vachhrajani  13 , David F Bauer  14   15
Affiliations

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for Patients With Chiari Malformation: Symptoms

Eric M Jackson et al. Neurosurgery. .

Abstract

Background: Chiari I malformation (CIM) is characterized by descent of the cerebellar tonsils through the foramen magnum, potentially causing symptoms from compression or obstruction of the flow of cerebrospinal fluid. Diagnosis and treatment of CIM is varied, and guidelines produced through systematic review may be helpful for clinicians.

Objective: To perform a systematic review of the medical literature to answer specific questions on the diagnosis and treatment of CIM.

Methods: PubMed and Embase were queried between 1946 and January 23, 2021, using the search strategies provided in Appendix I of the full guidelines.

Results: The literature search yielded 430 abstracts, of which 79 were selected for full-text review, 44 were then rejected for not meeting the inclusion criteria or for being off-topic, and 35 were included in this systematic review.

Conclusion: Four Grade C recommendations were made based on Class III evidence, and 1 question had insufficient evidence. The full guidelines can be seen online at https://www.cns.org/guidelines/browse-guidelines-detail/2-symptoms .

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References

    1. Aitken LA, Lindan CE, Sidney S, et al. Chiari type I malformation in a pediatric population. Pediatr Neurol. 2009;40(6):449-454.
    1. Meadows J, Kraut M, Guarnieri M, Haroun RI, Carson BS. Asymptomatic Chiari Type I malformations identified on magnetic resonance imaging. J Neurosurg. 2000;92(6):920-926.
    1. Morris Z, Whiteley WN, Longstreth WT Jr, et al. Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ. 2009;339:b3016-b3550.
    1. Strahle J, Muraszko KM, Kapurch J, Bapuraj JR, Garton HJ, Maher CO. Chiari malformation Type I and syrinx in children undergoing magnetic resonance imaging. J Neurosurg Pediatr. 2011;8(2):205-213.
    1. Vernooij MW, Ikram MA, Tanghe HL, et al. Incidental findings on brain MRI in the general population. New Engl J Med. 2007;357(18):1821-1828.

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