Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2023 Aug 30:12:e91145.
doi: 10.7554/eLife.91145.

Studying behavior under constrained movement

Ranier Gutierrez  1
Affiliations
Editorial

Studying behavior under constrained movement

Ranier Gutierrez. Elife. .

Abstract

A new platform for studying how brain activity is linked to behavior enables researchers to perform diverse experiments on mice that have their heads immobilized.

Keywords: ingestive behavior; motivation; mouse; neuroscience; neuroscience tools; reward.

PubMed Disclaimer

Conflict of interest statement

RG No competing interests declared

Figures

Figure 1.
Figure 1.. A new platform for studying behaviors related to motivation in head-fixed mice.
(A) Operant configuration: mice are trained to rotate a wheel to the left or right to obtain sucrose, to trigger stimulation of certain brain areas, or to express real-time preference and avoidance behavior. (B) Consummatory configuration: multiple spouts (represented as lines) carrying solutions with varying levels of sucrose are consecutively rotated in front of the head-fixed mouse for them to consume. The brain activity, release of neurochemicals, and behavior of the mice is then recorded to see how they respond to these different tasting solutions.
See this image and copyright information in PMC

Comment on

References

    1. Allen WE, Chen MZ, Pichamoorthy N, Tien RH, Pachitariu M, Luo L, Deisseroth K. Thirst regulates motivated behavior through modulation of brainwide neural population dynamics. Science. 2019;364:eaav3932. doi: 10.1126/science.aav3932. - DOI - PMC - PubMed
    1. Benson B, Benson J, Birman D, Bonacchi N, Carandini M, Catarino JA, Chapuis GA, Churchland AK, Dan Y, Dayan P, DeWitt EE, Engel TA, Fabbri M, Faulkner M, Fiete IR, Findling C, Freitas-Silva L, Gerçek B, Harris KD, Häusser M, Hofer SB, Hu F, Hubert F, Huntenburg JM, Khanal A, Krasniak C, Langdon C, Lau PYP, Mainen ZF, Meijer GT, Miska NJ, Mrsic-Flogel TD, Noel JP, Nylund K, Pan-Vazquez A, Pouget A, Rossant C, Roth N, Schaeffer R, Schartner M, Shi Y, Socha KZ, Steinmetz NA, Svoboda K, Urai AE, Wells MJ, West SJ, Whiteway MR, Winter O, Witten IB, International Brain Laboratory A Brain-Wide Map of Neural Activity during Complex Behaviour. bioRxiv. 2023 doi: 10.1101/2023.07.04.547681. - DOI
    1. Buzsaki G. The Brain from Inside Out. Oxford University Press; 2021. - DOI
    1. Evarts EV. Relation of pyramidal tract activity to force exerted during voluntary movement. Journal of Neurophysiology. 1968;31:14–27. doi: 10.1152/jn.1968.31.1.14. - DOI - PubMed
    1. Gordon-Fennell A, Barbakh JM, Utley MT, Singh S, Bazzino P, Gowrishankar R, Bruchas MR, Roitman MF, Stuber GD. An open-source platform for head-fixed operant and consummatory behavior. eLife. 2023;12:e86183. doi: 10.7554/eLife.86183. - DOI - PMC - PubMed