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. 2023 Aug 30;25(3):35.
doi: 10.1007/s10544-023-00662-2.

A flexible implant for acute intrapancreatic electrophysiology

Domenic Pascual  1 , Lisa Brauns  1 , Ruth Domes  1 , Matthias Tisler  2 , Marco Kögel  1 , Angelika Stumpf  1 , Andreas Kirschniak  3   4 , Jens Rolinger  3   4 , Udo Kraushaar  1 , Peter D Jones  5
Affiliations

A flexible implant for acute intrapancreatic electrophysiology

Domenic Pascual et al. Biomed Microdevices. .

Abstract

Microelectrode arrays (MEAs) have proven to be a powerful tool to study electrophysiological processes over the last decades with most technology developed for investigation of the heart or brain. Other targets in the field of bioelectronic medicine are the peripheral nervous system and its innervation of various organs. Beyond the heart and nervous systems, the beta cells of the pancreatic islets of Langerhans generate action potentials during the production of insulin. In vitro experiments have demonstrated that their activity is a biomarker for blood glucose levels, suggesting that recording their activity in vivo could support patients suffering from diabetes mellitus with long-term automated read-out of blood glucose concentrations. Here, we present a flexible polymer-based implant having 64 low impedance microelectrodes designed to be implanted to a depth of 10 mm into the pancreas. As a first step, the implant will be used in acute experiments in pigs to explore the electrophysiological processes of the pancreas in vivo. Beyond use in the pancreas, our flexible implant and simple implantation method may also be used in other organs such as the brain.

Keywords: Beta cells; Depth recording; Diabetes mellitus; Islets of Langerhans; Microelectrode array; Pancreas.

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References

    1. N. Albeck et al., Temperature-robust rapid eye movement and slow wave sleep in the lizard Laudakia vulgaris. Commun. Biol. 5(1), 1310 (2022). https://doi.org/10.1038/s42003-022-04261-4 - DOI
    1. N.V. Apollo et al., Gels, jets, mosquitoes, and magnets: a review of implantation strategies for soft neural probes. J. Neural. Eng. 17(4), 041002 (2020). https://doi.org/10.1088/1741-2552/abacd7 - DOI
    1. K.C. Cheung, Implantable microscale neural interfaces. Biomed. Microdevice. 9(6), 923–938 (2007). https://doi.org/10.1007/s10544-006-9045-z - DOI
    1. X. Dai et al., Mesh nanoelectronics: seamless integration of electronics with tissues. Acc. Chem. Res. 51(2), 309–318 (2018). https://doi.org/10.1021/acs.accounts.7b00547 - DOI
    1. R. Daschner et al., Laboratory and clinical reliability of conformally coated subretinal implants. Biomed. Microdevice. 19(1), 7 (2017). https://doi.org/10.1007/s10544-017-0147-6 - DOI

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