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. 2023 Aug;11(8):e992.
doi: 10.1002/iid3.992.

High systemic immune-inflammation index is relevant to osteoporosis among middle-aged and older people: A cross-sectional study

Suli Zhang  1   2   3 , Wenyan Ni  1   2   3
Affiliations

High systemic immune-inflammation index is relevant to osteoporosis among middle-aged and older people: A cross-sectional study

Suli Zhang et al. Immun Inflamm Dis. 2023 Aug.

Abstract

Background: As one of novel inflammatory indexes proposed in recent years, systemic immune-inflammation index (SII) can comprehensively reflect the inflammatory and immune state of the body. This study aims to explore the relationship between SII and osteoporosis among middle-aged and older people.

Materials and methods: Our study includes 20,497 individuals from National Health and Nutrition Examination Survey (NHANES) 2005-2008, and target study population are confined to people aged 45 years and above. SII is calculated as platelet count × neutrophil count/lymphocyte count. Multivariate logistic regression analysis is used to explore the link between SII and osteoporosis, and receiver operating characteristics curve is used to screen optimal cut-off value of SII for indicating the occurrence of osteoporosis.

Results: A total of 435 people with osteoporosis are screened among 4625 middle-aged and older people, and individuals in osteoporosis group have higher SII than those in nonosteoporosis group (p = .024). Logistic regression analysis indicates that with the enhancement of SII, prevalence of osteoporosis in each tertile category also increases (p < .001). This tendency is also not changed in univariate model (p < .001), as well as the adjustments for different parameters. Moreover, we also identify that SII of 530.09 is the optimal cut-off value for indicating the occurrence of osteoporosis among middle-aged and older people.

Conclusions: This present NHANES-based study noticed that higher SII is positively linked to osteoporosis among middle-aged and older people, and SII should not exceed 530.09 for them to obtain a potentially lower risk of osteoporosis.

Keywords: NHANES; middle-aged and older people; osteoporosis; systemic immune-inflammation index.

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Conflict of interest statement

The authors declare no conflicts of interests.

Figures

Figure 1
Figure 1
The flow chart of the sample screening in NHANES 2005–2008. NHANES, National Health and Nutrition Examination Survey.
Figure 2
Figure 2
The SII of 530.09 (with 53.6% specificity and 53.8% sensitivity) is identified as an optimal cut‐off value for predicting the risk of osteoporosis through ROC curve, and the AUC is 0.535. AUC, area under the curve; ROC, receiver operating characteristic; SII, systemic immune‐inflammation index.
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