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Review
. 2023 Sep 15;88(18):12867-12871.
doi: 10.1021/acs.joc.3c01264. Epub 2023 Aug 30.

seco-1-Azacubane-2-carboxylic acid-Amide Bond Comparison to Proline

Tyler Fahrenhorst-Jones  1 , Dehui Kong  1 , Jed M Burns  1 , Gregory K Pierens  2 , Paul V Bernhardt  1 , G Paul Savage  3 , Craig M Williams  1
Affiliations
Review

seco-1-Azacubane-2-carboxylic acid-Amide Bond Comparison to Proline

Tyler Fahrenhorst-Jones et al. J Org Chem. .

Abstract

seco-1-Azacubane-2-carboxylic acid, an unusual and sterically constrained amino acid, was found to undergo amide bond formation at both the N- and C-termini using proline based bioactive molecule templates as a concept platform.

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