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. 2023 Aug;61(3):310-316.
doi: 10.3347/PHD.22172. Epub 2023 Aug 21.

Elevated interleukin-10 levels in patients with ocular toxoplasmosis

Gee-Hyun Kim  1 , Jae Hyuck Kwak  1 , Young-Hoon Park  1
Affiliations

Elevated interleukin-10 levels in patients with ocular toxoplasmosis

Gee-Hyun Kim et al. Parasites Hosts Dis. 2023 Aug.

Abstract

In elderly patients, ocular toxoplasmosis is one of the most common etiologies of uveitis, which should be differentially diagnosed from ocular lymphoma, another common pathology of uveitis in older adults. The high level of interleukin (IL)-10 and an IL-10/IL-6 ratio higher than 1 (>1.0) are helpful parameters to diagnose ocular lymphoma. In this study, we used aqueous humor samples to detect 4 cases of ocular toxoplasmosis in patients with high levels of IL-10 and an IL-10/IL-6 ratio higher than 1. Our results show that ocular toxoplasmosis may be associated with increased cytokine levels in aqueous humor.

Keywords: Interleukin-10; Toxoplasma gondii; cytokines; intraocular lymphoma; ocular toxoplasmosis; uveitis.

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Conflict of interest statement

None of the authors have any conflicting interests to disclose.

Figures

Fig. 1
Fig. 1
Fundus photographs of vitritis (headlight in the fog) with active lesions seen as whitish foci of retinochoroiditis which is marked by white dotted circles; (A) left eye of case 1, (B) left eye of case 2, (C) left eye of case 3, (D) right eye of case 4, and (E) unaffected left eye of case 4.
Fig. 2
Fig. 2
Fundus fluorescein angiographs of papillitis and vasculitis in an ocular toxoplasmosis patient; (A) left eye of case 1, (B) right eye of case 4.
Fig. 3
Fig. 3
Fundus photography of total retinal detachment associated with active ocular toxoplasmosis (left eye of case 3).
See this image and copyright information in PMC

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References

    1. Subauste CS, Ajzenberg D, Kijlstra A. Review of the series “Disease of the year 2011: toxoplasmosis” pathophysiology of toxoplasmosis. Ocul Immunol Inflamm. 2011;19(5):297–306. doi: 10.3109/09273948.2010.605198. - DOI - PubMed
    1. Evering T, Weiss LM. The immunology of parasite infections in immunocompromised hosts. Parasite Immunol. 2006;28(11):549–565. doi: 10.1111/j.1365-3024.2006.00886.x. - DOI - PMC - PubMed
    1. Dodds EM. Toxoplasmosis. Curr Opin Ophthalmol. 2006;17(6):557–561. doi: 10.1097/ICU.0b013e32801094ca. - DOI - PubMed
    1. Gilbert RE, Dunn DT, Lightman S, Murray PI, Pavesio CE, et al. Incidence of symptomatic toxoplasma eye disease: aetiology and public health implications. Epidemiol Infect. 1999;123(2):283–289. doi: 10.1017/s0950268899002800. - DOI - PMC - PubMed
    1. McCannel CA, Holland GN, Helm CJ, Cornell PJ, Winston JV, et al. Causes of uveitis in the general practice of ophthalmology. UCLA Community-Based Uveitis Study Group. Am J Ophthalmol. 1996;121(1):35–46. doi: 10.1016/s0002-9394(14)70532-x. - DOI - PubMed