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Review
. 2023 Oct;44(10):3379-3388.
doi: 10.1007/s10072-023-07044-9. Epub 2023 Aug 30.

Parkinsonism in complex neurogenetic disorders: lessons from hereditary dementias, adult-onset ataxias and spastic paraplegias

Simone Aloisio  1 , Sara Satolli  2 , Gabriele Bellini  3 , Piervito Lopriore  4
Affiliations
Review

Parkinsonism in complex neurogenetic disorders: lessons from hereditary dementias, adult-onset ataxias and spastic paraplegias

Simone Aloisio et al. Neurol Sci. 2023 Oct.

Abstract

Parkinsonism is a syndrome characterized by bradykinesia in combination with either rest tremor, rigidity, or both. These features are the cardinal manifestations of Parkinson's disease, the most common cause of parkinsonism, and atypical parkinsonian disorders. However, parkinsonism can be a manifestation of complex neurological and neurodegenerative genetically determined disorders, which have a vast and heterogeneous motor and non-motor phenotypic features. Hereditary dementias, adult-onset ataxias and spastic paraplegias represent only few of this vast group of neurogenetic diseases. This review will provide an overview of parkinsonism's clinical features within adult-onset neurogenetic diseases which a neurologist could face with. Understanding parkinsonism and its characteristics in the context of the aforementioned neurological conditions may provide insights into pathophysiological mechanisms and have important clinical implications, including diagnostic and therapeutic aspects.

Keywords: Familial Alzheimer’s disease; Frontotemporal dementia; Hereditary ataxia; Hereditary spastic paraplegia; Neurogenetics; Parkinsonism.

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Conflict of interest statement

The authors declare no conflict of interest. Figures created with BioRender.com.

Figures

Fig. 1
Fig. 1
Parkinsonism in hereditary dementias - key points
Fig. 2
Fig. 2
Parkinsonism in adult-onset ataxias - key points
Fig. 3
Fig. 3
Parkinsonism in hereditary spastic paraplegias - key points
See this image and copyright information in PMC

References

    1. Postuma RB, et al. MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord. 2015;30(12):1591–1601. doi: 10.1002/MDS.26424. - DOI - PubMed
    1. Bologna M, et al. Redefining bradykinesia. Mov Disord. 2023;38(4):551–557. doi: 10.1002/mds.29362. - DOI - PMC - PubMed
    1. Müller U, Graeber MB, Haberhausen G, Köhler A. Molecular basis and diagnosis of neurogenetic disorders. J Neurol Sci. 1994;124(2):119–140. doi: 10.1016/0022-510X(94)90318-2. - DOI - PubMed
    1. Samson WN, van Duijn CM, Hop WCJ, Hofman A. Clinical features and mortality in patients with early-onset Alzheimer’s disease. Eur Neurol. 1996;36(2):103–106. doi: 10.1159/000117218. - DOI - PubMed
    1. Cacace R, Sleegers K, Van Broeckhoven C. Molecular genetics of early-onset Alzheimer’s disease revisited. Alzheimers Dement. 2016;12(6):733–748. doi: 10.1016/J.JALZ.2016.01.012. - DOI - PubMed