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. 2023 Aug 30;23(1):528.
doi: 10.1186/s12877-023-04231-3.

Association between all-cause mortality and trajectories across quality and duration of sleep and cognitive function: based on Group-Based Multivariate Trajectory modeling

Jianlin Lin  1   2   3   4 , Jian Xiao  5 , Qiao Li #  6 , Li Cao #  7
Affiliations

Association between all-cause mortality and trajectories across quality and duration of sleep and cognitive function: based on Group-Based Multivariate Trajectory modeling

Jianlin Lin et al. BMC Geriatr. .

Abstract

Background: Sleep duration and quality are associated with cognition, but the interaction of the 3 indicators and their association with all-cause mortality is unclear.

Methods: We used data from the Chinese Longitudinal Healthy Longevity Survey from 2005-2018 to identify latent trajectories of sleep duration, sleep quality, and cognitive function. Secondly, the multinomial logistic model was adopted to determine predictors of trajectory groups. Finally, the Cox regression model was used to examine the association between these trajectory groups and all-cause mortality.

Results: A total of 5046 adults (49% women) with an average age of 76.34 were included in the study. The median follow-up period was 11.11 years, during which 1784 (35%) participants died. We identified 4 latent groups among older adults: 'Good-performance' (51%), 'Decreasing' (26%), 'Oversleep & cognitive impairment' (12%), and 'Sleep-deprived' (11%). Individuals in the 'Decreasing' had a 51% increased risk of all-cause mortality (HR = 1.51, 95% CI: 1.25 - 1.81, p < .001). Individuals in the 'Oversleep & cognitive impairment' had a 170% increased risk of all-cause mortality (HR = 2.7 95% CI: 2.13 - 3.43, p < .001). Women had a higher risk of all-cause mortality regardless of trajectory group (47-143% men VS. 74-365% women). Both urban and rural areas have a similarly increased risk of all-cause mortality (48-179%).

Conclusions: Our study reveals the latent trajectories across sleep duration, sleep quality, and cognitive function in older Chinese and further explores their association with death. These findings provide a rational basis for cognitive interventions and reduce all-cause mortality.

Keywords: Cognitive function; Older adults; Sleep duration; Sleep quality; Trajectory.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Statistical metrics for model selection
Fig. 2
Fig. 2
Latent trajectory shape for 5 groups across sleep quality, sleep duration, and cognition function
See this image and copyright information in PMC

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References

    1. Chen WC, Wang XY. Longitudinal associations between sleep duration and cognitive impairment in Chinese elderly. Front Aging Neurosci. 2022;14:1037650. doi: 10.3389/fnagi.2022.1037650. - DOI - PMC - PubMed
    1. Kronholm E, Sallinen M, Suutama T, Sulkava R, Era P, Partonen T. Self-reported sleep duration and cognitive functioning in the general population. J Sleep Res. 2009;18:436–446. doi: 10.1111/j.1365-2869.2009.00765.x. - DOI - PubMed
    1. Virta JJ, Heikkila K, Perola M, et al. Midlife sleep characteristics associated with late life cognitive function. Sleep. 2013;36:1533–1541, 1541A. doi: 10.5665/sleep.3052. - DOI - PMC - PubMed
    1. Faubel R, Lopez-Garcia E, Guallar-Castillon P, Graciani A, Banegas JR, Rodriguez-Artalejo F. Usual sleep duration and cognitive function in older adults in Spain. J Sleep Res. 2009;18:427–435. doi: 10.1111/j.1365-2869.2009.00759.x. - DOI - PubMed
    1. Loerbroks A, Debling D, Amelang M, Sturmer T. Nocturnal sleep duration and cognitive impairment in a population-based study of older adults. Int J Geriatr Psychiatry. 2010;25:100–109. - PubMed

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