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Case Reports
. 2023 Aug 18;7(8):ytad412.
doi: 10.1093/ehjcr/ytad412. eCollection 2023 Aug.

Gastrointestinal bleeding associated to aortic valve stenosis (Heyde's syndrome): a case series and literature review

Caterina Chiara De Carlini  1 , Edoardo Cantù  2 , Nicoletta Erba  3 , Stefano Maggiolini  2
Affiliations
Case Reports

Gastrointestinal bleeding associated to aortic valve stenosis (Heyde's syndrome): a case series and literature review

Caterina Chiara De Carlini et al. Eur Heart J Case Rep. .

Abstract

Background: The association among aortic valve stenosis, gastrointestinal bleeding, and anaemia due to arteriovenous malformations, known as Heyde's syndrome (HS), is poorly understood and controversial. Recently, acquired Type 2A von Willebrand syndrome (vWS 2A) was shown to be the most likely aetiological mechanism of anaemia.

Case summary: We report two cases of HS in whom the percutaneous replacement of the aortic valve was resolutive for iron deficiency anaemia.

Discussion: Iron deficiency anaemia and aortic stenosis are a common association in the elderly, so much that frequently; in such cases, the correction of the valvulopathy is often excluded as pre-operative anaemia is associated with higher morbidity and mortality. From this perspective, the correct diagnosis of HS is crucial to guide the decision to correct valvulopathy, as valvular substitution is resolutive for both anaemic disorders and aortic stenosis.

Keywords: Anaemia; Aortic stenosis; Case report; Gastrointestinal bleeding; Heyde’s syndrome; Transcatheter aortic valve implantation.

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Conflict of interest statement

Conflict of interest: None declared.

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