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Comment
. 2023 Sep 1;8(1):325.
doi: 10.1038/s41392-023-01590-6.

Boosting T cell immunity against cytomegalovirus: a potential strategy combating human aging and age-related diseases

Matthias Wirth  1   2   3 , Walburgis Brenner  4 , Oliver H Krämer  5
Affiliations
Comment

Boosting T cell immunity against cytomegalovirus: a potential strategy combating human aging and age-related diseases

Matthias Wirth et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

No author has an actual or perceived conflict of interest with the contents of this article. O.H.K. declares the patents WO2019/034538, WO2016020369A1, and WO/2004/027418. Two of them cover substance classes that are discussed in this work.

Figures

Fig. 1
Fig. 1
Cellular senescence is characterized by a replicative arrest that can be induced by various stress stimuli. In aged skin, the population of senescent cells can be controlled by CXCL9-attracted cytotoxic CD4+ T lymphocytes (CD4+ CTLs). HLA-II-dependent presentation of human cytomegalovirus glycoprotein B (HCMV-gB) and high expression of the activating surface receptor of cytotoxic immune cells (NKG2D) and its HLA-I related ligand UL16-binding protein-2 (ULBP2) mark senescent fibroblasts for CD4+ CTLs-mediated killing. Figure created with BioRender.com
See this image and copyright information in PMC

Comment on

References

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