Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Sep;4(9):1239-1257.
doi: 10.1038/s43018-023-00617-9. Epub 2023 Aug 31.

Clinical and translational advances in ovarian cancer therapy

Panagiotis A Konstantinopoulos  1 , Ursula A Matulonis  2
Affiliations
Review

Clinical and translational advances in ovarian cancer therapy

Panagiotis A Konstantinopoulos et al. Nat Cancer. 2023 Sep.

Abstract

Ovarian cancer is an aggressive disease that is frequently detected at advanced stages and is initially very responsive to platinum-based chemotherapy. However, the majority of patients relapse following initial surgery and chemotherapy, highlighting the urgent need to develop new therapeutic strategies. In this Review, we outline the main therapeutic principles behind the management of newly diagnosed and recurrent epithelial ovarian cancer and discuss the current landscape of targeted and immune-based approaches.

PubMed Disclaimer

References

    1. Sung, H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71, 209–249 (2021). - PubMed - DOI
    1. Dalmartello, M. et al. European cancer mortality predictions for the year 2022 with focus on ovarian cancer. Ann. Oncol. 33, 330–339 (2022). - PubMed - DOI
    1. Siegel, R. L., Miller, K. D., Fuchs, H. E. & Jemal, A. Cancer statistics, 2022. CA Cancer J. Clin. 72, 7–33 (2022). - PubMed - DOI
    1. Cancer Genome Atlas Research Network Integrated genomic analyses of ovarian carcinoma. Nature 474, 609–615 (2011).
    1. Gershenson, D. M. et al. The genomic landscape of low-grade serous ovarian/peritoneal carcinoma and its impact on clinical outcomes. Gynecol. Oncol. 165, 560–567 (2022). - PubMed - DOI

Publication types

LinkOut - more resources