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. 2023 Dec;34(12):2121-2132.
doi: 10.1007/s00198-023-06895-4. Epub 2023 Aug 31.

Estimating the economic burden of osteoporotic fractures in a multinational study: a real-world data perspective

A Moayyeri  1 , J Warden  1 , S Han  2 , H S Suh  3   4 , R Pinedo-Villanueva  5 , N C Harvey  6   7 , J R Curtis  8 , S Silverman  9 , J K Multani  10 , E J Yeh  11
Affiliations

Estimating the economic burden of osteoporotic fractures in a multinational study: a real-world data perspective

A Moayyeri et al. Osteoporos Int. 2023 Dec.

Abstract

Fracture-related costs vary by country. A standardized methodology and presentations were proposed to fairly assess the economic burden of osteoporotic fracture. Results indicated substantial costs of osteoporotic fractures for pharmacy, hospitalization, emergency care, and outpatient visits in women aged ≥ 50 years in Australia, Germany, South Korea, Spain, and the USA.

Purpose: The objective of this multinational, retrospective matched cohort study was to use a standardized methodology across different healthcare systems to estimate the burden of osteoporotic fracture (OF) in women aged ≥ 50 years in Australia, Germany, South Korea, Spain, and the USA.

Methods: Within each country, healthcare resource utilization and direct costs of care were compared between patients with newly identified OF and a propensity score-matched cohort without OF during follow-up periods of up to 5 years.

Results: Across all five countries, the OF cohort had significantly higher rates and length of inpatient admissions compared with the non-OF cohort. In each country, the adjusted total costs of care ratio between OF and non-OF cohorts were significant. The adjusted cost ratios for pharmacy, inpatient care, emergency care, and outpatient visits were similarly higher in the OF cohort across countries.

Conclusion: The current study demonstrates the substantial economic burden of OF across different countries when compared with matched non-OF patients. The findings would assist stakeholders and policymakers in developing appropriate health policies.

Keywords: Fractures; Healthcare resource utilization; Osteoporosis; Real-world evidence; Research methods.

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Conflict of interest statement

Alireza Moayyeri is an employee of UCB Pharma and holds UCB stocks. Joshua Warden is an employee of UCB Pharma with no UCB stock. Sola Han has no conflict of interest. Hae Sun Suh received a research grant from Amgen Inc. to conduct the South Korean study of this work at Kyung Hee University. Rafael Pinedo-Villanueva has received research funding from the UK NIHR, the International Osteoporosis Foundation, Kyowa Kirin Services, Fondation privée des HUG (Geneva, Switzerland), Amgen Inc., and the Royal Osteoporosis Society and lecture fees and/or consulting honoraria from Amgen Inc., UCB, Kyowa Kirin Services, Astellas, the International Osteoporosis Foundation, and Mereo BioPharma. Nicholas C. Harvey reports personal fees, consultancy, lecture fees, and honoraria from Alliance for Better Bone Health, Amgen Inc., MSD, Eli Lilly, UCB, Kyowa Kirin, Servier, Shire, Consilient Healthcare, and Internis Pharmaceuticals, outside the submitted work. Jeffrey R. Curtis reports consulting fees and research grants from Amgen Inc. Stuart Silverman received research grants, consulting fees, and honoraria from Amgen Inc., and honoraria from Radius Health. Jasjit K. Multani is an employee of IQVIA, which was contracted by Amgen Inc. and UCB to conduct the Australia, Spain, and US studies of this work. Eric J. Yeh is an employee of Amgen Inc. and holds Amgen stock.

Figures

Fig. 1
Fig. 1
Study design. The study periods for the Germany and US studies reflect the latest available data at the time of the study and are different from dates shown above. OF, osteoporotic fracture. *Study period for Germany: July 1, 2013, to December 31, 2018; for the USA: July 1, 2013, to December 31, 2020. **Subject identification period for Germany: July 1, 2014, to November 30, 2020; for the USA: January 1, 2015, to November 30, 2020. ‡There were 12 panels during the subject identification period; each panel had 6-month panel to identify subjects, except the last panel which had a 5-month period to allow a 1-month follow-up period
See this image and copyright information in PMC

References

    1. Williams SA, Chastek B, Sundquist K, Barrera-Sierra S, Leader D, Jr, Weiss RJ, Wang Y, Curtis JR. Economic burden of osteoporotic fractures in US managed care enrollees. Am J Manag Care. 2020;26:e142–e149. doi: 10.37765/ajmc.2020.43156. - DOI - PubMed
    1. Kaffashian S, Raina P, Oremus M, Pickard L, Adachi J, Papadimitropoulos E, Papaioannou A. The burden of osteoporotic fractures beyond acute care: the Canadian Multicentre Osteoporosis Study (CaMos) Age Ageing. 2011;40:602–607. doi: 10.1093/ageing/afr085. - DOI - PMC - PubMed
    1. Watts J, Abimanyi-Ochom J, Sanders K (2013) Osteoporosis costing all Australians. A new burden of disease analysis 2012-2022. https://healthybonesaustralia.org.au/wp-content/uploads/2020/11/Burden-o.... Accessed 28 September 2022
    1. Borgström F, Karlsson L, Ortsäter G, et al. Fragility fractures in Europe: burden, management and opportunities. Arch Osteoporos. 2020;15:59. doi: 10.1007/s11657-020-0706-y. - DOI - PMC - PubMed
    1. Kim HY, Ha YC, Kim TY, Cho H, Lee YK, Baek JY, Jang S. Healthcare costs of osteoporotic fracture in Korea: information from the National Health Insurance Claims Database, 2008-2011. J Bone Metab. 2017;24:125–133. doi: 10.11005/jbm.2017.24.2.125. - DOI - PMC - PubMed