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. 2023 Sep 1;10(1):36.
doi: 10.1186/s40662-023-00354-1.

Rates of infectious keratitis and other ocular surface adverse events in corneal cross-linking for keratoconus and corneal ectasias performed in an office-based setting: a retrospective cohort study

Farhad Hafezi  1   2   3   4   5 , Emilio A Torres-Netto  6 , Leonard Kollros  6 , Nan-Ji Lu  6 , Nikki Hafezi  6 , Cosimo Mazzotta  7   8   9 , M Enes Aydemir  10   6 , Mark Hillen  6
Affiliations

Rates of infectious keratitis and other ocular surface adverse events in corneal cross-linking for keratoconus and corneal ectasias performed in an office-based setting: a retrospective cohort study

Farhad Hafezi et al. Eye Vis (Lond). .

Erratum in

Abstract

Background: This study aimed to compare the complication rates of epithelium-off corneal cross-linking (epi-off CXL) performed in an office-based setting with those of epi-off CXL performed in an operating room.

Methods: A retrospective cohort study, comprising 501 consecutive epi-off CXL procedures, performed in a non-sterile procedure room without laminar flow ventilation at the ELZA Institute in Zurich, Switzerland, between November 2015 and October 2021, was conducted.

Results: No cases of postoperative infectious keratitis were observed, while sterile infiltrates occurred in 10 out of 501 (2.00%) patients, all of whom responded well to topical steroid therapy. Delayed epithelialization (> 7 days) occurred in 14 out of 501 (2.79%) patients. No other adverse events were noted.

Conclusions: Office-based epi-off CXL does not appear to be associated with an increased risk of complications when compared to operating room settings.

Keywords: Cornea; Corneal cross-linking; Epithelium-off; Infectious keratitis; Keratoconus; Office-based; Slit lamp; Sterile infiltrates.

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Conflict of interest statement

NH is CEO of EMAGine AG, a company producing a CXL device. FH holds a patent on a UV light source (PCT/CH 2012/000090) and is CSO of EMAGine AG. FH is an editorial board member of Eye and Vision. The other authors have no proprietary or commercial interest in any of the materials discussed in this article.

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